Plant and Marine-Derived Natural Product Research in Drug Discovery: Strengths and Perspective

doi:10.3390/books978-3-0365-6810-2

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https://mdpi.com/books/pdfview/book/6834

Contributor(s)

Duarte, Noelia (editor)

Language

English

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Abstract

For centuries, nature has been an inspirational source for the discovery of drugs used in modern medicine. Nowadays, natural-based treatments continue to be employed for primary health care, particularly playing a significant role in folk medicine. In addition, we are currently observing an increasing use of natural-products-based supplements from botanical and marine sources, making their standardization and scientific validation a priority to guarantee the safety of these products. Natural products and/or synthetic derivatives using their novel structures have also been of utmost importance in drug discovery and development in several clinical areas. After a period of discreditation and reduced investment, we are now witnessing a renewed interest from the pharmaceutical industry and scientific community due to the urgent need to develop new drugs. This reprint comprises 11 original and 6 review articles dedicated to plant and marine natural products research, contributing to the scientific validation of their use and opening new perspectives in drug discovery

URI

https://directory.doabooks.org/handle/20.500.12854/98078

Keywords

propyl-propane-thiosulfinate; propyl-propane-thiosulfonate; antibacterial activity; antifungal activity; vapor; mycosporines; mycosporine-like amino acids (MAAs); mass spectrometry; database; photoprotective compounds; UV-absorbing compounds; melatonin; endoplasmic reticulum stress; diabesity; kidney; cellulite; essential oil; monoterpenes; Thai herbal compress; adipogenesis; lipolysis; vasorelaxation; Asphodelus ramosus; root-tubers; inulin; fructans; fructooligosaccharide; alkaline extraction; high-performance thin layer chromatography; NMR spectroscopy; 2D NMR analyses; infrared spectroscopy; isofuranodiene; Smyrnium olusatrum L.; ischemic stroke; NF-ĸB; IL-1β; TNF-α; Plectranthus; royleanone; 7α-acetoxy-6β-hydroxyroyleanone; ent-abietane; antitumoral activity; antimicrobial activity; antioxidant; Euphorbia; flavonoids; pharmacological activities; structure–activity relationship; Sambucus nigra L.; ethosomes; collagenase inhibition; skin compatibility; anthocyanins; antioxidants; dietary source; bioavailability; biological activity; biosynthesis; Posidonia oceanica; autophagy; lipid accumulation; NAFLD; herbal medicine; amphotericin B; candidiasis; gel; Bursera graveolens; topical treatment; linarin; chemotaxonomy; phytochemistry; bioactivities; (−)-usnic acid; evernic acid; salazinic acid; secondary metabolites; lichen extracts; Garcinia indica; kokum; wild mangosteen; pharmacological activity; terpenoids; Trypanosoma; human African trypanosomiasis; sleeping disease; human American trypanosomiasis; Chagas disease; anticancer activity; cytotoxicity; Hymenocardia acida; nanoencapsulation; nanoparticle; plant extract; PLGA; n/a