O-GlcNAcylation and Cancer

doi:10.3390/books978-3-0365-3082-6

Download Url(s)

https://mdpi.com/books/pdfview/book/4917

Contributor(s)

El Yazidi-Belkoura, Ikram (editor)

Lefebvre, Tony (editor)

Language

English

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Abstract

This book gathers reviews and articles on the role of O-GlcNAcylation in cancer underlying the pharmacological targeting of the O-GlcNAcylation enzymes OGT and OGA as a promising anticancer strategy. Particular attention is paid to the involvement of O-GlcNAcylation in the regulation of transcription and as a link between nutrition and epigenetic dynamics or cellular energy metabolism. The role of O-GlcNAcylation in metastasis, immune responses, and resistance to chemotherapeutic agents is also discussed.

URI

https://directory.doabooks.org/handle/20.500.12854/78822

Keywords

UNC5A; O-GlcNAcylation; OGT; EZH2; nutrition; epigenetics; colon cancer; transcription; O-GlcNAc; O-GlcNAc transferase; O-GlcNAcase; mOGT; mitochondria; glucose; energy metabolism; breast cancer; cellular stress; cancer; immune surveillance; invasiveness; lung adenocarcinoma; SAM68