Toxicological Effects of Mycotoxins on Target Cells

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https://mdpi.com/books/pdfview/book/2837Contributor(s)
Juan-García, Ana (editor)
Language
EnglishAbstract
Mycotoxins are a Public Health concern that in last year have reached the top 10 food and product hazard categories in the Rapid Alert System for Food and Feed (RASFF), with almost six hundred notifications. The toxicological effects of mycotoxins are evaluated through the extrapolation of results from in vivo and in vitro assays. Studies of mycotoxins’ effects at the cellular level precede those in organs and systems. All these studies are key steps for risk assessment and following legislation for mycotoxins. This Special Issue of Toxins comprises 10 original contributions and two reviews. The Issue reports new findings regarding toxic mechanisms, the use of innovative techniques to study the potential toxicity of mycotoxins not only individually but in combination, reflecting a real scenario according to current studies of mycotoxins.
Keywords
Destruxin A; Bombyx mori; binding protein; BmTudor-sn; Bm12 cell; Ochratoxin A (OTA); human Stem Cells; mycotoxins; cells; cytotoxicity; cell culture; T-2 toxin; HT-2 toxin; apoptosis; autophagy; endophyte; fungi; neurotoxin; lolitrems; ochratoxin A; beauvericin; mixtures; HepG2 cells; genotoxicity; cell cycle; Fusarium; Aspergillus; Penicillium; Alternaria; emerging mycotoxin; in vitro; IPEC-J2; occurrence data; trichothecene; biosynthetic pathway; acetyltransferase; deacetylase; deoxynivalenol; 3-acetyldeoxynivalenol; isotrichodermol; isotrichodermin; differentiated Caco-2 cells; cell apoptosis; transcriptome analysis; hepatocyte; chicken; acute toxicity; combined toxicity; cell protection; silibinin; in silico prediction; co-culture models; mycotoxin interaction; Loewe additivity; combination index; isobologram; Chou-Talalay method; MixLow; IPEC-J2 cells; RNA-seq; inflammation; MAPKs; n/aWebshop link
https://mdpi.com/books/pdfview ...ISBN
9783039369263, 9783039369270Publisher website
www.mdpi.com/booksPublication date and place
Basel, Switzerland, 2020Classification
Medicine and Nursing

