Model-Based Tools for Pharmaceutical Manufacturing Processes

Gernaey, Krist V.; Schenkendorf, Rene; Gerogiorgis, Dimitrios I.; Mansouri, Seyed Soheil

doi:10.3390/books978-3-03928-425-2

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https://mdpi.com/books/pdfview/book/2084

Author(s)

Gernaey, Krist V.

Schenkendorf, Rene

Gerogiorgis, Dimitrios I.

Mansouri, Seyed Soheil

Language

English

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Abstract

The Special Issue on “Model-Based Tools for Pharmaceutical Manufacturing Processes” will curate novel advances in the development and application of model-based tools to address ever-present challenges of the traditional pharmaceutical manufacturing practice as well as new trends. This book provides a collection of nine papers on original advances in the model-based process unit, system-level, quality-by-design under uncertainty, and decision-making applications of pharmaceutical manufacturing processes.

URI

https://directory.doabooks.org/handle/20.500.12854/53667

Keywords

n/a; sensitivity analysis; parametric probability-box; non-isothermal modelling; dynamic optimisation; batch-to-batch variation; pharmaceutical manufacturing; process kinetics; flowsheet modeling; continuous manufacturing; MATLAB Production Server; flexibility analysis; polynomial chaos; probabilistic design space; bypassing; ODE model; enzymatic reaction; enzymatic synthesis; parameter estimation; freeze-drying; reversible reaction; diffusion of innovation; multi-objective decision-making; software development; continuous stirred tank reactor; parenteral manufacturing; wet granulation; spectroscopic assay; process design; dynamic modelling; quality by design; Fourier analysis; residence time distribution; point estimate method; model integration; global optimization; robust process design; pharmaceutical processes; return on investment; Amoxicillin; pyrimidine-nucleoside phosphorylase; spray drying; single-use technology; global sensitivity analysis; process modeling