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dc.contributor.editorWarrington, Junie P
dc.contributor.editorPalei, Ana T.
dc.contributor.editorCunningham, Mark W.
dc.contributor.editorAmaral, Lorena M.
dc.date.accessioned2023-02-02T16:49:48Z
dc.date.available2023-02-02T16:49:48Z
dc.date.issued2023
dc.identifierONIX_20230202_9783036564111_172
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/96771
dc.description.abstractPreeclampsia is a hypertensive disorder of pregnancy, diagnosed after the 20th week of gestation in women experiencing new-onset hypertension along with symptoms affecting the liver, kidneys, or brain. In some cases, women with preeclampsia develop novel seizures or unexplained coma, at which time they are diagnosed with eclampsia. The mechanisms contributing to preeclampsia and eclampsia are not fully elucidated, although the placenta seems to play a critical role. Previous studies suggest that improper placentation stimulates mitochondrial dysfunction and the exaggerated release of placental-derived molecules including inflammatory cytokines, anti-angiogenic factors, reactive oxygen species, and cell-free nucleic acids into the maternal circulation that cause systemic vascular dysfunction. These, along with maternally derived molecules, act in concert, leading to hypertension and target organ damage during pregnancies complicated by preeclampsia and eclampsia.In this reprint, we present the original research articles and review papers published as part of the Special Issue: "The Pathophysiology of Preeclampsia and Eclampsia" in Cells.
dc.languageEnglish
dc.subject.classificationthema EDItEUR::M Medicine and Nursingen_US
dc.subject.otherpre-eclampsia
dc.subject.othereclampsia
dc.subject.otherpulmonary oedema
dc.subject.otherbiobank
dc.subject.otherdatabase
dc.subject.otherplacental ischemia
dc.subject.otherseizure
dc.subject.otherASIC2a
dc.subject.otherpregnancy
dc.subject.otherRUPP
dc.subject.otherpentylenetetrazol
dc.subject.othermelatonin
dc.subject.otherextracellular vesicle
dc.subject.otherexosome
dc.subject.otherpreeclampsia
dc.subject.othermisfold proteins
dc.subject.otherendothelial cell activation
dc.subject.otherp21Cip1/CDKN1A
dc.subject.othertrophoblasts
dc.subject.otherhypoxia
dc.subject.othertrophoblast organoids
dc.subject.otherfusion
dc.subject.otherangiotensin II
dc.subject.otherAGTR1 (angiotensin II receptor type 1)
dc.subject.otherbradykinin
dc.subject.otherBDKRB2 (bradykinin receptor B2)
dc.subject.otherAT1R-B2R heteromer (protein complex formed of AT1R-B2R)
dc.subject.otherG-protein-coupled receptor
dc.subject.otherprotein aggregation
dc.subject.otherARRB (beta-arrestin)
dc.subject.otherearly-onset preeclampsia
dc.subject.otherhemorheology
dc.subject.otherred blood cell aggregation
dc.subject.otherred blood cell deformability
dc.subject.othererythrocyte
dc.subject.otherhypertension
dc.subject.otherIL-2
dc.subject.otherinflammation
dc.subject.otheroxidative stress
dc.subject.othersFlt-1
dc.subject.otherNLRP3
dc.subject.othernitric oxide
dc.subject.otherendothelial dysfunction
dc.subject.otherneuroinflammation
dc.subject.otherblood–brain barrier
dc.subject.othercerebral edema
dc.subject.othergestation
dc.subject.othervessel
dc.subject.otherblood pressure
dc.subject.otherplacenta
dc.subject.othertrophoblast
dc.subject.otherfetal growth restriction
dc.subject.othermaternal chronic venous disease (CVeD)
dc.subject.otheranti-inflammation
dc.subject.otherantioxidant
dc.subject.otherischaemia
dc.subject.othervitamin E
dc.subject.otherglucose transporter 9
dc.subject.otherGLUT9
dc.subject.otheruric acid
dc.subject.othercardiac dysfunction
dc.subject.otherplacental factors
dc.subject.otheractivin A
dc.subject.otherG-protein-coupled receptors
dc.subject.otherGPCR
dc.subject.otherweighted gene correlation network analysis
dc.subject.otherWGCNA
dc.subject.otherblood-brain barrier
dc.subject.otherin vitro studies
dc.subject.othercerebral biomarkers
dc.subject.otherNfL
dc.subject.othertau
dc.subject.otherNSE
dc.subject.otherS100B
dc.subject.othernebivolol
dc.subject.otheradrenoceptor
dc.subject.otherobesity
dc.subject.otherbiomarkers
dc.subject.otheradipokines
dc.subject.otheradiponectin
dc.subject.otherleptin
dc.subject.otherROS
dc.subject.otherangiogenic factors
dc.subject.otherhypoxia/reoxygenation
dc.subject.othersFlT-1/PlGF ratio
dc.subject.otherprimary trophoblast
dc.titleThe Pathophysiology of Preeclampsia and Eclampsia
dc.typebook
oapen.identifier.doi10.3390/books978-3-0365-6410-4
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn9783036564111
oapen.relation.isbn9783036564104
oapen.pages334
oapen.place.publicationBasel


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