Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers

doi:10.3390/books978-3-0365-4645-2

dc.contributor.editor	Kutner, Andrzej
dc.contributor.editor	Brown, Geoffrey
dc.contributor.editor	Kallay, Enikö
dc.date.accessioned	2022-08-12T12:47:37Z
dc.date.available	2022-08-12T12:47:37Z
dc.date.issued	2022
dc.identifier	ONIX_20220812_9783036546469_52
dc.identifier.uri	https://directory.doabooks.org/handle/20.500.12854/91173
dc.description.abstract	This book is conceived to promote synergy between research and industrial activities in the design and development of new drugs and, therefore, is not limited to any specific aspect of development. It covers the entire process from the identification of a molecular target, studies of drug–protein interactions, the modeling and optimization of the functional activity, design and chemical synthesis, biological evaluation, and the development of new pharmaceutical carriers.The original articles and reviews are focused on the design and development of new anticancer treatments, new anticancer low-molecular-weight agents as potential drug substances, and the elucidation of their mechanisms of action. The book also includes studies on novel modulators of the serotonergic system used to treat central nervous system disorders, novel agents against infectious diseases, and the development of anti-plasmodial and anti-inflammatory agents. The successful identification of new compounds for development as drug substances comes from rich sources of medicinal plants and medicinal chemistry approaches.
dc.language	English
dc.subject.classification	thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general	en_US
dc.subject.classification	thema EDItEUR::P Mathematics and Science::PN Chemistry	en_US
dc.subject.other	alpha-ketoglutarate
dc.subject.other	cell cycle
dc.subject.other	apoptosis
dc.subject.other	JNK
dc.subject.other	cell migration
dc.subject.other	cell invasion
dc.subject.other	TGF-β
dc.subject.other	VEGF
dc.subject.other	glycoconjugates
dc.subject.other	methotrexate
dc.subject.other	cancer treatment
dc.subject.other	glucose metabolism
dc.subject.other	drug design and discovery
dc.subject.other	anticancer drugs
dc.subject.other	targeted therapy
dc.subject.other	Warburg effect
dc.subject.other	antidepressants
dc.subject.other	pyrido[1,2-c]pyrimidines
dc.subject.other	dual 5-HT1A/SERT activity
dc.subject.other	drug design
dc.subject.other	anticancer activity
dc.subject.other	lung cancer
dc.subject.other	resveratrol
dc.subject.other	PRI-2191
dc.subject.other	vitamin D
dc.subject.other	active substance delivery systems
dc.subject.other	biomedical hydrogels
dc.subject.other	active substance-controlled release
dc.subject.other	genistein
dc.subject.other	hydrogels for cosmetology
dc.subject.other	hydrogels for dermatology
dc.subject.other	transdermal active substance delivery systems
dc.subject.other	histone deacetylase (HDAC)
dc.subject.other	depression
dc.subject.other	biomarker
dc.subject.other	anti-depressant therapy
dc.subject.other	human DNA topoisomerase
dc.subject.other	cancer
dc.subject.other	drug
dc.subject.other	molecular docking
dc.subject.other	synthesis
dc.subject.other	fluorine
dc.subject.other	vitamin D3
dc.subject.other	metabolite
dc.subject.other	A-ring
dc.subject.other	CD-ring
dc.subject.other	side-chain
dc.subject.other	nanoparticles
dc.subject.other	molecular modeling
dc.subject.other	oxidation mechanisms
dc.subject.other	electrochemistry
dc.subject.other	MALDI
dc.subject.other	spectroscopic data
dc.subject.other	cytotoxic study
dc.subject.other	self-assembled monolayer
dc.subject.other	gold electrode
dc.subject.other	multimodal activity
dc.subject.other	calcium-sensing receptor
dc.subject.other	enantiomer
dc.subject.other	calcimimetic
dc.subject.other	calcilytic
dc.subject.other	colon cancer
dc.subject.other	stereospecificity
dc.subject.other	HT-29
dc.subject.other	IL-8
dc.subject.other	inflammation
dc.subject.other	cyclooxygenase
dc.subject.other	1,2,4-triazole
dc.subject.other	pyridazinone
dc.subject.other	SAR
dc.subject.other	anti-inflammatory activity
dc.subject.other	antioxidant activity
dc.subject.other	ADME
dc.subject.other	anticancer drug
dc.subject.other	antimicrobial peptide (AMP)
dc.subject.other	dermaseptin
dc.subject.other	frog skin peptides
dc.subject.other	LHRH
dc.subject.other	prostate cancer
dc.subject.other	Phyllomedusa bicolor
dc.subject.other	therapeutic peptides
dc.subject.other	copper (II) complexes
dc.subject.other	thiourea
dc.subject.other	cytotoxic activity
dc.subject.other	proteome analysis
dc.subject.other	antimicrobial activity
dc.subject.other	major latex protein
dc.subject.other	Chelidonium majus
dc.subject.other	greater celandine
dc.subject.other	defense-related proteins
dc.subject.other	alkaloids
dc.subject.other	cancer cells
dc.subject.other	vitamin D receptor
dc.subject.other	split luciferase-based biosensor
dc.subject.other	CYP24A1-dependent metabolism
dc.subject.other	CYP27B1
dc.subject.other	rickets
dc.subject.other	genome editing
dc.subject.other	vitamin D biology and action
dc.subject.other	transcription
dc.subject.other	ChIP-chip analysis
dc.subject.other	distal enhancers
dc.subject.other	histone H3 acetylation
dc.subject.other	RNA polymerase II
dc.subject.other	analogue actions at genes
dc.subject.other	vitamin D hormone (1,25(OH)2D3)
dc.subject.other	latex
dc.subject.other	antiviral proteins
dc.subject.other	antimicrobial compounds
dc.subject.other	cytotoxicity
dc.subject.other	drug discovery
dc.subject.other	CRISPR/Cas9
dc.subject.other	tetrahydro-β-carbolines
dc.subject.other	Plasmodium falciparum (P. falciparum)
dc.subject.other	antimalarial
dc.subject.other	antiparasitic agents
dc.subject.other	hemolysis
dc.subject.other	vitamin D analogs
dc.subject.other	25 vitamin D 24-hydroxylase
dc.subject.other	CYP24A1
dc.subject.other	proliferation
dc.subject.other	high-grade serous ovarian cancer cells
dc.subject.other	gold
dc.subject.other	Au(III) complex
dc.subject.other	colorectal cancer
dc.subject.other	organometallic
dc.subject.other	cancer therapy
dc.subject.other	metallodrugs
dc.subject.other	n/a
dc.title	Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers
dc.type	book
oapen.identifier.doi	10.3390/books978-3-0365-4645-2
oapen.relation.isPublishedBy	46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn	9783036546469
oapen.relation.isbn	9783036546452
oapen.pages	450
oapen.place.publication	Basel

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