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dc.contributor.editorKopecka, Joanna
dc.date.accessioned2022-06-21T08:37:49Z
dc.date.available2022-06-21T08:37:49Z
dc.date.issued2022
dc.identifierONIX_20220621_9783036540399_56
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/84478
dc.description.abstractMitochondria, organelles surrounded by a double membrane and with their own small genome, are the cells’ energy centers. Besides the production of ATP through cellular respiration, mitochondria play a pivotal role in other aspects of the life and death of a cell: heat production, programmed cell death, the regulation of metabolic activity, immunity, and calcium homeostasis. A number of diseases are associated with mitochondrial dysfunction, including cardiovascular, neurological, inflammatory, and metabolic disorders as well as cancer. Mitochondria therefore represent an important therapy target, and it is not surprising that a number of different treatment strategies have emerged. Approaches targeting mitochondria can be split into two opposite categories: drugs that restore mitochondrial function and drugs that trigger mitochondria-mediated cell death. Targeted drug delivery to achieve the selective accumulation of drug molecules in mitochondria is complex and involves methods such as direct drug modification or encapsulation into nanocarriers.
dc.languageEnglish
dc.subject.classificationbic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
dc.subject.classificationbic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
dc.subject.otherretinal ischemia
dc.subject.otherblood–brain barrier
dc.subject.otherendothelial
dc.subject.otherreactive oxygen species
dc.subject.otheroxidative stress
dc.subject.othertunneling nanotubules
dc.subject.otherneuron
dc.subject.othercentral nervous system
dc.subject.otherinflammation
dc.subject.otherhypoxia
dc.subject.otheranticancer peptide (ACP)
dc.subject.otherantimicrobial peptide (AMP)
dc.subject.otheranticancer peptides
dc.subject.otherantimicrobial peptides
dc.subject.otherhost defense peptides
dc.subject.otherprediction
dc.subject.otherrandom forest
dc.subject.othermitochondria
dc.subject.othermitochondrial DNA
dc.subject.othermitochondrial disorders
dc.subject.otherpharmacological therapy
dc.subject.othergene therapy
dc.subject.otherprecision medicine
dc.subject.othercardiovascular disease
dc.subject.otherdrug delivery
dc.subject.othermitochondria dysfunctions
dc.subject.othernanocarriers
dc.subject.otheroxoglutarate carrier
dc.subject.othermalate-aspartate shuttle
dc.subject.othercancer metabolism
dc.subject.otherATP production
dc.subject.otherdiphenyleneiodonium
dc.subject.otherNADPH-oxidase
dc.subject.otherdifferentiation
dc.subject.otherproliferation
dc.subject.othermitochondria-targeted antioxidants
dc.subject.otherLPS
dc.subject.othermitochondrial ROS
dc.subject.otherantitumor agents
dc.subject.otherfluorescence lifetime imaging
dc.subject.othermedicinal chemistry
dc.subject.othermetabolic drug
dc.subject.othermitochondrial carrier
dc.subject.othermelanoma
dc.subject.otherplumbagin
dc.subject.othercytotoxic effect
dc.subject.othermetabolism
dc.subject.othercholesterol
dc.subject.otherlipid raft
dc.subject.othermitochondrial permeability transition pore
dc.subject.otheralkylphospholipid analog
dc.subject.otheredelfosine
dc.subject.othermitochondrial oncometabolites
dc.subject.othercancer drug resistance
dc.subject.othermitochondrial disease
dc.subject.otherheteroplasmy
dc.subject.othermitochondrial gene delivery
dc.subject.othern/a
dc.titleMitochondria-targeted drug delivery
dc.typebook
oapen.identifier.doi10.3390/books978-3-0365-4040-5
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn9783036540399
oapen.relation.isbn9783036540405
oapen.pages290
oapen.place.publicationBasel


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