Drug Metabolism/Transport and Pharmacokinetics

doi:10.3390/books978-3-0365-2458-0

dc.contributor.editor	Song, Im-Sook
dc.date.accessioned	2022-01-11T13:51:16Z
dc.date.available	2022-01-11T13:51:16Z
dc.date.issued	2021
dc.identifier	ONIX_20220111_9783036524597_902
dc.identifier.uri	https://directory.doabooks.org/handle/20.500.12854/77070
dc.description.abstract	This book serves to highlight the pharmacokinetics/drug–drug interactions and mechanistic understanding in relation to the drug-metabolizing enzymes and drug transporters.This book presents a series of drug metabolism and transport mechanisms that govern the pharmacokinetic features of therapeutic drugs as well as natural herbal medicines. It also covers the pharmacokinetic interactions caused by inhibiting or inducing the metabolic or transport activities under disease states or the coadministration of potential inhibitors. It also deals with microenvironmental pharmacokinetic profiles as well as population pharmacokinetics, which gives new insights regarding the pharmacokinetic features with regard to drug metabolism and transporters.
dc.language	English
dc.subject.classification	thema EDItEUR::M Medicine and Nursing	en_US
dc.subject.classification	thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries	en_US
dc.subject.other	tofacitinib
dc.subject.other	dose-dependent pharmacokinetics
dc.subject.other	hepatic and intestinal first-pass effect
dc.subject.other	rats
dc.subject.other	catalposide
dc.subject.other	in vitro human metabolism
dc.subject.other	UDP-glucuronosyltransferase
dc.subject.other	sulfotransferase
dc.subject.other	carboxylesterase
dc.subject.other	celecoxib
dc.subject.other	drug–drug interaction
dc.subject.other	fluorescence
dc.subject.other	HPLC
dc.subject.other	metabolism
dc.subject.other	repaglinide
dc.subject.other	HSG4112
dc.subject.other	anti-obesity agent
dc.subject.other	stereoselectivity
dc.subject.other	pharmacokinetics
dc.subject.other	compound K
dc.subject.other	protopanaxadiol (PPD)
dc.subject.other	biliary excretion
dc.subject.other	intestinal metabolism
dc.subject.other	Carthamus tinctorius extract
dc.subject.other	notoginseng total saponins
dc.subject.other	comparative pharmacokinetic study
dc.subject.other	large volume direct injection
dc.subject.other	compatibility mechanism
dc.subject.other	mertansine
dc.subject.other	human hepatocytes
dc.subject.other	cytochrome P450
dc.subject.other	UDP-glucuronosyltransferases
dc.subject.other	sodium-glucose cotransporter 2 (SGLT2) inhibitors
dc.subject.other	DWP16001
dc.subject.other	kidney distribution
dc.subject.other	inhibition mode
dc.subject.other	diabetes
dc.subject.other	transporter-enzyme interplay
dc.subject.other	influx transporter
dc.subject.other	efflux transporter
dc.subject.other	physiologically based pharmacokinetic model
dc.subject.other	cytochrome P450 enzymes
dc.subject.other	tiropramide
dc.subject.other	healthy Korean subjects
dc.subject.other	modeling
dc.subject.other	population pharmacokinetic
dc.subject.other	quercetin
dc.subject.other	breast cancer resistance protein
dc.subject.other	inhibitor
dc.subject.other	prazosin
dc.subject.other	sulfasalazine
dc.subject.other	kinetic analysis
dc.subject.other	food–drug interactions
dc.subject.other	Caco-2
dc.subject.other	EpiIntestinal
dc.subject.other	first-pass
dc.subject.other	P-gp
dc.subject.other	BCRP
dc.subject.other	drug transporter
dc.subject.other	CYP3A4
dc.subject.other	oral availability
dc.subject.other	automatization
dc.subject.other	drug absorption
dc.subject.other	drug dosing
dc.subject.other	head-and-neck cancer
dc.subject.other	real-time measurements
dc.subject.other	taxanes
dc.subject.other	tissue engineering
dc.subject.other	UHPLC-MS/MS
dc.subject.other	metformin
dc.subject.other	verapamil
dc.subject.other	drug interaction
dc.subject.other	organic cation transporter 2
dc.subject.other	renal excretion
dc.subject.other	acute renal failure
dc.subject.other	gentamicin
dc.subject.other	cisplatin
dc.subject.other	hepatic CYP3A1(23)
dc.subject.other	creatinine clearance
dc.subject.other	renal clearance
dc.subject.other	nonrenal clearance
dc.title	Drug Metabolism/Transport and Pharmacokinetics
dc.type	book
oapen.identifier.doi	10.3390/books978-3-0365-2458-0
oapen.relation.isPublishedBy	46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn	9783036524597
oapen.relation.isbn	9783036524580
oapen.pages	232
oapen.place.publication	Basel, Switzerland

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