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Transmucosal Absorption Enhancers in the Drug Delivery Field

dc.contributor.authorMaher, Sam*
dc.contributor.authorIllum, Lisbeth*
dc.contributor.authorCasettari, Luca*
dc.date.accessioned2021-02-12T06:26:41Z
dc.date.available2021-02-12T06:26:41Z
dc.date.issued2020*
dc.date.submitted2020-01-30 16:39:46*
dc.identifier43619*
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/61237
dc.description.abstractDevelopment of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.*
dc.languageEnglish*
dc.subjectR5-920*
dc.subjectRM1-950*
dc.subject.classificationthema EDItEUR::M Medicine and Nursingen_US
dc.subject.otherchitosan*
dc.subject.otherintestinal epithelial cells*
dc.subject.otherocular delivery*
dc.subject.otheramphiphilic polymers*
dc.subject.othercornea*
dc.subject.othertight junction modulator*
dc.subject.othercyclodextrin*
dc.subject.otherpermeability*
dc.subject.othergemini surfactant*
dc.subject.othertransferrin*
dc.subject.othercompound 48/80*
dc.subject.otherepithelial permeability*
dc.subject.othercervicovaginal tumors*
dc.subject.othernanoparticles*
dc.subject.otherconfocal laser scanning microscopy*
dc.subject.othersafety*
dc.subject.otherformulation*
dc.subject.othersalcaprozate sodium*
dc.subject.otherintestinal absorption*
dc.subject.otherFITC-dextran*
dc.subject.othercurcumin*
dc.subject.otherblock copolymers*
dc.subject.othernasal vaccination*
dc.subject.otherwhole leaf*
dc.subject.otherbrush border*
dc.subject.otherocular drug delivery*
dc.subject.othervaccine adjuvant*
dc.subject.othernanoparticle*
dc.subject.othernasal delivery*
dc.subject.otherefflux*
dc.subject.otherpermeation enhancers*
dc.subject.otherabsorption enhancers*
dc.subject.othernose to brain delivery*
dc.subject.othersmall intestine*
dc.subject.otherepithelium*
dc.subject.otherCNS disorders*
dc.subject.otherabsorption modifying excipients*
dc.subject.otherinsulin*
dc.subject.otherabsorption enhancer*
dc.subject.othergel*
dc.subject.otherintestinal delivery*
dc.subject.otherthermogel system*
dc.subject.otherCaco-2*
dc.subject.otherbiocompatibility studies*
dc.subject.otherabsorption enhancement*
dc.subject.otherman*
dc.subject.otherPN159*
dc.subject.otherpoorly absorbed drug*
dc.subject.othertryptophan*
dc.subject.othertight junction*
dc.subject.otheroral macromolecule delivery*
dc.subject.otherpenetration enhancer*
dc.subject.otherintestinal permeation enhancers*
dc.subject.othernanocrystals*
dc.subject.othersimvastatin*
dc.subject.othernanomedicine*
dc.subject.otherenterocyte*
dc.subject.otherN-dodecyl-?-D-maltoside (DDM)*
dc.subject.othercell-penetrating peptide*
dc.subject.otherquaternization*
dc.subject.otherKLAL*
dc.subject.othernasal*
dc.subject.othernasal permeability*
dc.subject.othertransmucosal drug delivery*
dc.subject.otherCaco-2 cells*
dc.subject.othermast cell activator*
dc.subject.otherpenetration enhancers*
dc.subject.otherdrug delivery*
dc.subject.othernose-to-brain*
dc.subject.otherbioenhancer*
dc.subject.otherpolymeric micelles*
dc.subject.othermucoadhesion*
dc.subject.othercell-penetrating peptide (CPP)*
dc.subject.othersimulated intestinal fluid*
dc.subject.othervaginal delivery*
dc.subject.othernasal formulation*
dc.subject.otherpharmacokinetic interaction*
dc.subject.othersodium caprate*
dc.subject.otherclinical trial*
dc.subject.othertransmucosal permeation*
dc.subject.otherdrug absorption enhancer*
dc.subject.othersugar-based surfactants*
dc.subject.othernanocapsules*
dc.subject.otherimatinib*
dc.subject.otherteriparatide*
dc.subject.otherosteoporosis*
dc.subject.otherhydrophobization*
dc.subject.otherF-actin*
dc.subject.othercombined microsphere*
dc.subject.othertransepithelial electrical resistance*
dc.subject.otheroral delivery*
dc.subject.otherocular conditions*
dc.subject.othermetabolism*
dc.subject.otherantimicrobial peptide*
dc.subject.otherpermeation enhancer*
dc.subject.otherdrug administration*
dc.subject.otherantiepileptic drug*
dc.subject.otheramino acid*
dc.subject.otherin vivo studies*
dc.subject.othersodium cholate (NaC)*
dc.subject.otherepithelial transport*
dc.subject.otherpreclinical*
dc.subject.othernose to brain transport*
dc.subject.otherpharmacokinetics*
dc.subject.otherchitosan derivatives*
dc.subject.otherophthalmology*
dc.subject.othertight junctions*
dc.subject.othersheep*
dc.subject.othercationic functionalization*
dc.subject.otherGLP-1*
dc.subject.otherpulmonary*
dc.subject.otherand liposome*
dc.subject.othercytochrome P450*
dc.subject.otherclaudin*
dc.subject.otherP-glycoprotein*
dc.subject.otherin situ hydrogel*
dc.subject.othermucoadhesiveness*
dc.subject.otherPTH 1-34*
dc.subject.otherAloe vera*
dc.subject.otheroral peptides*
dc.titleTransmucosal Absorption Enhancers in the Drug Delivery Field*
dc.typebook
oapen.identifier.doi10.3390/books978-3-03921-849-3*
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0*
oapen.relation.isbn9783039218493*
oapen.relation.isbn9783039218486*
oapen.pages406*
oapen.edition1st*


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