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Advances in Single Molecule, Real-Time (SMRT) Sequencing

dc.contributor.authorAmeur, Adam*
dc.contributor.authorHestand, Matthew S.*
dc.date.accessioned2021-02-11T07:50:44Z
dc.date.available2021-02-11T07:50:44Z
dc.date.issued2019*
dc.date.submitted2019-12-09 11:49:16*
dc.identifier42642*
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/40355
dc.description.abstractPacBio’s single-molecule real-time (SMRT) sequencing technology offers important advantages over the short-read DNA sequencing technologies that currently dominate the market. This includes exceptionally long read lengths (20 kb or more), unparalleled consensus accuracy, and the ability to sequence native, non-amplified DNA molecules. From fungi to insects to humans, long reads are now used to create highly accurate reference genomes by de novo assembly of genomic DNA and to obtain a comprehensive view of transcriptomes through the sequencing of full-length cDNAs. Besides reducing biases, sequencing native DNA also permits the direct measurement of DNA base modifications. Therefore, SMRT sequencing has become an attractive technology in many fields, such as agriculture, basic science, and medical research. The boundaries of SMRT sequencing are continuously being pushed by developments in bioinformatics and sample preparation. This book contains a collection of articles showcasing the latest developments and the breadth of applications enabled by SMRT sequencing technology.*
dc.languageEnglish*
dc.subjectQH301-705.5*
dc.subjectQR1-502*
dc.subjectQ1-390*
dc.subject.classificationthema EDItEUR::P Mathematics and Science::PS Biology, life sciencesen_US
dc.subject.othern/a*
dc.subject.otherCladobotryum protrusum*
dc.subject.otherallele-specific analysis*
dc.subject.otherlow-input DNA*
dc.subject.otherfull length RNAseq*
dc.subject.otherde novo genome assembly*
dc.subject.otherde novo assembly*
dc.subject.otherhuman reference genome*
dc.subject.otherTricoplusia ni*
dc.subject.otherPacBio single molecule real-time sequencing*
dc.subject.othersecondary metabolite*
dc.subject.otherprotein isoforms*
dc.subject.otherbone marrow cell subpopulations*
dc.subject.otherDNA methylation*
dc.subject.othermycoparasite*
dc.subject.otherhuman whole-genome sequencing*
dc.subject.otherGRCh38*
dc.subject.otherSMRT sequencing*
dc.subject.othercytochrome P450 enzyme (CYP)*
dc.subject.othermRNA isoforms*
dc.subject.othernext generation sequencing*
dc.subject.othercobweb disease*
dc.subject.otherSwedish population*
dc.subject.othermosquito*
dc.subject.otherlong-read SMRT sequencing*
dc.subject.otherwhole genome sequencing*
dc.subject.otherterpenoid*
dc.subject.otherinsect genome*
dc.subject.otheroptical mapping*
dc.subject.otherGloeostereum incarnatum*
dc.subject.otherpopulation sequencing*
dc.subject.otherstatistical methods*
dc.subject.othergene expression*
dc.subject.othersingle molecule real-time sequencing*
dc.subject.otherPacBio*
dc.titleAdvances in Single Molecule, Real-Time (SMRT) Sequencing*
dc.typebook
oapen.identifier.doi10.3390/books978-3-03921-701-4*
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0*
oapen.relation.isbn9783039217014*
oapen.relation.isbn9783039217007*
oapen.pages128*
oapen.edition1st*


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