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dc.contributor.authorEdgington, Matthew P.
dc.contributor.authorAlphey, Luke
dc.date.accessioned2023-07-18T04:43:36Z
dc.date.available2023-07-18T04:43:36Z
dc.date.issued2022
dc.date.submitted2023-07-12T13:31:41Z
dc.identifierhttps://library.oapen.org/handle/20.500.12657/63877
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/101467
dc.description.abstractIn this chapter, we outline a range of modelling approaches that have been used to demonstrate the key characteristics of this approach, including threshold introduction frequencies, reversibility, spatial limitation and robustness to mutation/resistance. We then go on to discuss alternative configurations based on the use of sex-specific components and their effect on introduction thresholds. We conclude with a discussion on the cycle of information between mathematical models and experimental data along with a range of areas for future modelling that will be important in providing information on the anticipated effects of these systems when released into target populations.
dc.languageEnglish
dc.rightsopen access
dc.subject.classificationbic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
dc.subject.othergene drives; engineerd underdominance
dc.titleChapter 12 Modelling Threshold-Dependent Gene Drives: a Case Study Using Engineered Underdominance
dc.typechapter
oapen.identifier.doi10.1079/9781800621176.0012
oapen.relation.isPublishedByf69fb9b2-0428-45ab-aaf5-f4bd898185c7
oapen.relation.isPartOfBookTransgenic Insects
oapen.relation.isPartOfBookdb5428bc-1979-43ca-802c-b46722098d8f
oapen.relation.isFundedByd859fbd3-d884-4090-a0ec-baf821c9abfd
oapen.relation.isFundedByf6fcd900-36e2-4bc9-939e-ad820802e21f
oapen.relation.isbn9781800621152
oapen.relation.isbn9781800621176
oapen.collectionWellcome
oapen.pages20
oapen.grant.number110117/Z/15/Z
dc.relationisFundedByd859fbd3-d884-4090-a0ec-baf821c9abfd


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