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Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach

dc.contributor.editorVolcho, Konstantin
dc.contributor.editorLavrik, Olga
dc.date.accessioned2023-07-14T14:28:09Z
dc.date.available2023-07-14T14:28:09Z
dc.date.issued2023
dc.identifierONIX_20230714_9783036578811_72
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/101373
dc.description.abstractAlthough DNA repair enzymes play a crucial role in maintaining the integrity of the genome, the hyperactivity of certain enzymes of the DNA repair system can lead to the resistance of tumors to chemo- and radiotherapy, aimed at damaging the DNA of cancer cells. Therefore, the inhibition of DNA repair enzymes could help to overcome this resistance. The reviews and research articles included in this collection describe the molecular mechanisms of action of some important enzymes of the DNA repair system, as well as some new inhibitors of such enzymes and the pharmacological properties of these inhibitors. This reprint clearly demonstrates the importance of the inhibition of DNA repair enzymes to fight various diseases, especially cancer.
dc.languageEnglish
dc.subject.classificationthema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: generalen_US
dc.subject.classificationthema EDItEUR::P Mathematics and Science::PS Biology, life sciencesen_US
dc.subject.otherpoly (ADP-ribose) polymerase inhibitor
dc.subject.othernon-small cell lung cancer
dc.subject.otherDNA damage
dc.subject.otherradiotherapy
dc.subject.otherchemotherapy
dc.subject.othercombination therapy
dc.subject.othercoumarin
dc.subject.otherneoflavone
dc.subject.otherDNA repair enzymes
dc.subject.otherTdp1 inhibitor
dc.subject.othercancer
dc.subject.othertumor
dc.subject.othertopotecan
dc.subject.othertopoisomerase 1 inhibitors
dc.subject.othermolecular modeling
dc.subject.otherchemical space
dc.subject.othermorpholino nucleosides
dc.subject.otherNAD+ analogs
dc.subject.otherDNA repair
dc.subject.otherPARP
dc.subject.other7-methylguanine
dc.subject.otherpoly(ADP-ribose) polymerase 1
dc.subject.otherinhibitor
dc.subject.othernucleosome
dc.subject.othertrapping
dc.subject.otherdocking
dc.subject.othermolecular dynamics
dc.subject.otherfluorescence anisotropy
dc.subject.otherspFRET microscopy
dc.subject.otherDNA glycosylases
dc.subject.otherdrug targets
dc.subject.otherAPE1
dc.subject.otherprotein–protein interactions
dc.subject.otherbase excision repair
dc.subject.othermultifunctional disordered protein
dc.subject.otherfluorescence techniques
dc.subject.othercell cycle checkpoint
dc.subject.othercancer therapy
dc.subject.otherDNA repair inhibitors
dc.subject.othersynthetic lethality
dc.subject.otherfused in sarcoma
dc.subject.otherpoly(ADP-ribose) polymerase
dc.subject.otherpoly(ADP-ribose)
dc.subject.otherprotein phase separation
dc.subject.otherberberine
dc.subject.othertetrahydroberberine
dc.subject.otherDNA repair enzyme
dc.subject.otherSAR
dc.subject.otherpoly(ADP-ribosylation)
dc.subject.otherPARP-1
dc.subject.otherOlaparib
dc.subject.otherKU55933
dc.subject.otherKU-0060648
dc.subject.otherSCR7 pyrazine
dc.subject.otherVERO cells
dc.subject.othersynergism
dc.subject.otherresistance
dc.subject.otherCDKN2A
dc.subject.othersoft tissue sarcomas (STS)
dc.subject.othergastrointestinal stromal tumors (GIST)
dc.subject.otherAKT signaling
dc.subject.otherRad51 recombinase
dc.subject.otherhomology-mediated DNA repair
dc.subject.otherapoptosis
dc.subject.othersensitization
dc.subject.otherXPA
dc.subject.otherERCC1-XPF
dc.subject.otherCSB
dc.subject.otherUVB radiation
dc.subject.otherUVB mutagenesis
dc.subject.othernucleotide excision repair (NER)
dc.subject.othercyclobutane–pyrimidine dimer (CPD) photolesion
dc.subject.otherveliparib
dc.subject.otherresveratrol
dc.subject.otherarsenic trioxide
dc.subject.otherspironolactone
dc.subject.otherusnic acid
dc.subject.otherthioether
dc.subject.othertyrosyl-DNA phosphodiesterase 1
dc.subject.otherTDP1 inhibitor
dc.subject.otherinhibiting activity
dc.subject.otherTDP2
dc.subject.otherPARP1
dc.subject.othersynergy
dc.subject.otherHEK293 knockout cell line
dc.subject.otherpolyphenols
dc.subject.otherPARP-1 inhibitors
dc.subject.othern/a
dc.titleInhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach
dc.typebook
oapen.identifier.doi10.3390/books978-3-0365-7880-4
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn9783036578811
oapen.relation.isbn9783036578804
oapen.pages316
oapen.place.publicationBasel


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