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The Ins and Outs of miRNAs as Biomarkers

dc.contributor.editorIacomino, Giuseppe
dc.contributor.editorLauria, Fabio
dc.date.accessioned2023-07-14T14:26:00Z
dc.date.available2023-07-14T14:26:00Z
dc.date.issued2023
dc.identifierONIX_20230714_9783036579252_47
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/101348
dc.description.abstractmiRNAs are small noncoding RNAs that control gene expression at the post-transcriptional level. It has been recognized that dysregulation of miRNAs reflects the state and function of cells and tissues, contributing to their dysfunction. The identification of hundreds of extracellular miRNAs in biological fluids has underscored their potential in the field of biomarker research. In addition, the therapeutic potential of miRNAs is receiving increasing attention in numerous conditions. On the other hand, many operational issues, including stability, delivery systems, and bioavailability, have yet to be resolved. In this dynamic field, biopharmaceutical companies are increasingly engaged, and ongoing clinical trials point to anti-miR and miR-mimic molecules as novel classes of molecules for upcoming therapeutic applications. This reprint aims to provide a broad overview of current knowledge on several outstanding issues and new opportunities offered by miRNAs in the treatment of diseases and as early diagnostic tools for next-generation medicine.
dc.languageEnglish
dc.subject.classificationthema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: generalen_US
dc.subject.classificationthema EDItEUR::P Mathematics and Science::PS Biology, life sciencesen_US
dc.subject.othermi-RNA
dc.subject.otherphysical exercise
dc.subject.othergene expression
dc.subject.otherstress
dc.subject.otherhead and neck cancer
dc.subject.othermiRNA
dc.subject.otherchemoresistance
dc.subject.otherprotocol
dc.subject.othersystematic review
dc.subject.otherhazard ratio
dc.subject.otherpatient survival
dc.subject.otherup-regulation
dc.subject.otherdown-regulation
dc.subject.othermicroRNA
dc.subject.othercirculating miRNA
dc.subject.othertheranostic biomarkers
dc.subject.otherchemosensitivity
dc.subject.othermelanoma
dc.subject.othermeta-analysis
dc.subject.othermiRNAs
dc.subject.othermicroRNAs
dc.subject.otherliver neoplasms
dc.subject.otherangiogenesis
dc.subject.othercancer biomarkers
dc.subject.othertransfection
dc.subject.otherqRT-PCR
dc.subject.otherplasma
dc.subject.otheramplification efficiency
dc.subject.otherEBV
dc.subject.otherLMP1
dc.subject.othernasopharyngeal cells
dc.subject.otherexpression profiling
dc.subject.otherchronic low-grade inflammation
dc.subject.otherinflammation-associated biomarkers
dc.subject.otheroverweight and obesity
dc.subject.otherchildren/adolescents
dc.subject.othersex-related associations
dc.subject.otherDNA copy number variation
dc.subject.othercomparative study
dc.subject.otherprogenitor cells
dc.subject.otheramniotic fluid
dc.subject.otherleiomyoma
dc.subject.othermyometrium
dc.subject.otherdivergent cell commitment
dc.subject.otherlinear dysregulation
dc.subject.othercirculating microRNAs
dc.subject.otherextracellular miRNA
dc.subject.othernasopharyngeal carcinoma
dc.subject.othermiRNA-based diagnosis
dc.subject.otherHNSCC
dc.subject.othertumor-suppressor
dc.subject.othermiR-30e-5p
dc.subject.otherFOXD1
dc.subject.otherTCGA
dc.subject.othercervical cancer
dc.subject.othernon-coding RNAs
dc.subject.otherdiagnosis
dc.subject.otherprognosis
dc.subject.othertherapeutics
dc.subject.otherregulation of gene expression
dc.subject.otheralveolar epithelial type II cells
dc.subject.othertype II pneumocytes
dc.subject.otherATII
dc.subject.otherAECII
dc.subject.otherflow cytometry
dc.subject.otherautofluorescence
dc.subject.otherpathway analysis
dc.subject.otherTGF-beta
dc.subject.otherhomeostasis
dc.subject.otherEMT
dc.subject.otherRNA-based therapeutic
dc.subject.otherpersonalized medicine
dc.subject.othertranslational medicine
dc.subject.otherbreast cancer
dc.subject.otherdiagnostics
dc.subject.othertherapy response
dc.subject.otherhepatitis C virus
dc.subject.otherliver injury
dc.subject.othermicroRNA-192
dc.subject.othermicroRNA-29a
dc.subject.otherHCV genotype-3
dc.titleThe Ins and Outs of miRNAs as Biomarkers
dc.typebook
oapen.identifier.doi10.3390/books978-3-0365-7924-5
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn9783036579252
oapen.relation.isbn9783036579245
oapen.pages254
oapen.place.publicationBasel


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