Advances in Antifungal Development: Discovery of New Drugs and Drug Repurposing

doi:10.3390/books978-3-0365-4767-1

Download Url(s)

https://mdpi.com/books/pdfview/book/5854

Contributor(s)

Kim, Jong Heon (editor)

Cheng, Luisa W. (editor)

Land, Kirkwood (editor)

Language

English

Show full item record

Abstract

This reprint describes recent advances made in the field of antifungal development, especially the discovery of new drugs and drug repurposing. The articles presented in this book provide useful information and insight for the development of new antifungal drugs or intervention strategies. The identification of new, safe molecules, and cellular targets, as well as the elucidation of their antifungal mechanisms of action, will further the effective control of fungal pathogens, especially those resistant to current therapeutic agents.

URI

https://directory.doabooks.org/handle/20.500.12854/91208

Keywords

nanoparticles; fungi; drug delivery systems; marine; biological synthesis; myconanotechnology; canesten; clotrimazole; vulvovaginal; vaginitis; mycosis; candidosis; yeast infection; candida; candida albicans; vaginal health; anticandidal activity; indazole; pyrazole; 3-phenyl-1H-indazole; drug design; acetylsalicylic acid (ASA, aspirin); capsule; CAP64; Cryptococcus; membrane potential (ΔΨM); photodynamic treatment; photosensitiser; ultrastructure; drug repurposing; antifungals; repositioning; yeasts; emerging fungi; multidrug resistance; therapeutic alternatives; new targets; Candida auris; Aspergillus spp.; antifungal; beta-glucan; polycations; Galleria mellonella model; retinoids; Candida spp.; onychomycosis; Malassezia spp.; dermatophytes; microbiology; mycology; all-trans retinoic acid; Acanthamoeba; free-living ameba; Acanthamoeba keratitis; isavuconazonium sulfate; cyst; drug; drug discovery; drug targets; invasive aspergillosis treatment; invasive fungal infections; fission yeast; cell wall; β(1,3)-D-glucan synthase; antifungal drugs; echinocandin drugs; echinocandin resistance; Fks resistance hot spots; cytokinesis; septation; cell separation; cell integrity; cell lysis; sporotrichosis; Felis catus; quinones; hydrazones; zoonoses; host-directed drug therapy; azoles; polyenes; echinocandins; viral infections; azole; synergy; resistance; Candida; natural products; n/a