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dc.contributor.authorLange, F.
dc.contributor.authorBale, G.
dc.contributor.authorKaynezhad, P.
dc.contributor.authorPollock, R.D.
dc.contributor.authorStevenson, A.
dc.contributor.authorTachtsidis, I.
dc.date.accessioned2022-06-10T04:29:12Z
dc.date.available2022-06-10T04:29:12Z
dc.date.issued2020
dc.date.submitted2022-06-09T12:45:15Z
dc.identifierhttps://library.oapen.org/handle/20.500.12657/56699
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/84055
dc.description.abstractWe used a miniature broadband NIRS system to monitor concentration changes in brain oxygenation (oxy- and deoxy- haemoglobin [HbO2], [HHb]) and oxidised cytochrome-c-oxidase ([oxCCO]) during a high +Gz acceleration, induced by a human centrifuge, on two healthy experienced volunteers (2 male, 34 and 37 years). We performed a sequence of several +Gz exposures that were terminated at the onset of visual symptoms (loss of peripheral vision). Systemic parameters were recorded (i.e. heart rate, blood pressure and arterial saturation), and brain tissue blood volume changes ([HbT] = [HbO2] + [HHb]) and oxygen delivery ([HbDiff] = [HbO2] - [HHb]) were calculated. Volunteer 1 demonstrated a decrease in [HbT] of −3.49 ± 0.02 μMol and [HbDiff] of −3.23 ± 0.44 μMol, and an increase of [oxCCO] of 0.42 ± 0.01μMol. Volunteer 2 demonstrated a decrease in [HbDiff] of −4.37 ± 0.23 μMol, and no significant change in [HbT] (0.53 ± 0.06 μMol) and [oxCCO] (0.09 ± 0.06 μMol). The variability of the brain metabolic response was related to the level of ischaemia, suggesting that suppression of metabolism was due to lack of glucose substrate delivery rather than oxygen availability.
dc.languageEnglish
dc.rightsopen access
dc.subject.classificationbic Book Industry Communication::M Medicine::MB Medicine: general issues::MBG Medical equipment & techniques
dc.subject.otherNIRS, Broadband, Cytochrome-c-oxidase, Ischaemia, Human centrifuge
dc.titleChapter Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers
dc.typechapter
oapen.identifier.doi10.1007/978-3-030-34461-0_43
oapen.relation.isPublishedBy9fa3421d-f917-4153-b9ab-fc337c396b5a
oapen.relation.isPartOfBookOxygen Transport to Tissue XLI
oapen.relation.isPartOfBookffac1f1c-6a29-4ae5-b103-29b6b4354067
oapen.relation.isFundedByd859fbd3-d884-4090-a0ec-baf821c9abfd
oapen.relation.isFundedByf6fcd900-36e2-4bc9-939e-ad820802e21f
oapen.relation.isbn9783030344597
oapen.collectionWellcome
oapen.pages7
oapen.grant.number104580/Z/14/Z
dc.relationisFundedByd859fbd3-d884-4090-a0ec-baf821c9abfd


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