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dc.contributor.authorMartinelli, Serena
dc.date.accessioned2022-06-02T04:31:41Z
dc.date.available2022-06-02T04:31:41Z
dc.date.issued2017
dc.date.submitted2022-05-31T10:28:24Z
dc.identifierONIX_20220531_9788864535654_674
dc.identifier2612-8020
dc.identifierhttps://library.oapen.org/handle/20.500.12657/55390
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/83462
dc.description.abstractA gain-of-function mutation in Janus kinase 2 (JAK2V617F) is at the basis of the majority of chronic myeloproliferative neoplasms (MPN). Enhanced activation of other downstream pathways including the PI3K/mTOR pathway has been documented as well. In this study we evaluated the effects of JAK1/2 inhibitors, alone and in combination with mTOR, with a dual mTOR/PI3K inhibitor and with a pan PI3K inhibitor in in-vitro and in-vivo MPN models. Our findings of strong synergy between the JAK2 inhibitors and mTOR/PI3K inhibitor suggested that we might be able to administer these drugs at lower concentrations than when the drugs are used individually. This provides a framework for combination trials using compounds in patients with myeloproliferative neoplasms
dc.languageEnglish
dc.relation.ispartofseriesPremio Tesi di Dottorato
dc.rightsopen access
dc.subject.classificationthema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciencesen_US
dc.subject.classificationthema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQP Pharmacy / dispensingen_US
dc.subject.classificationthema EDItEUR::P Mathematics and Science::PS Biology, life sciencesen_US
dc.subject.classificationthema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistryen_US
dc.subject.classificationthema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biologyen_US
dc.titleStudy of intracellular signaling pathways in Chronic Myeloproliferative Neoplasms
dc.typebook
oapen.identifier.doi10.36253/978-88-6453-565-4
oapen.relation.isPublishedBy2ec4474d-93b1-4cfa-b313-9c6019b51b1a
oapen.relation.isbn9788864535654
oapen.relation.isbn9788864535647
oapen.relation.isbn9788892731684
oapen.pages80
oapen.place.publicationFlorence
dc.seriesnumber60


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open access
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