Show simple item record

dc.contributor.authorBernacchioni, Caterina
dc.date.accessioned2022-06-02T04:00:46Z
dc.date.available2022-06-02T04:00:46Z
dc.date.issued2012
dc.date.submitted2022-05-31T10:19:41Z
dc.identifierONIX_20220531_9788866552192_314
dc.identifier2612-8020
dc.identifierhttps://library.oapen.org/handle/20.500.12657/55030
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/81970
dc.description.abstractThis book gives an analysis of the role of the bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide 1-phosphate (C1P) in the skeletal muscle. The enzyme that produces S1P, sphingosine kinase 1 (SK1) has proved crucial in the biological action of growth factors and cytokines involved in the inflammatory process that follows muscular damage. Indeed, in myoblasts the cytokine TGFβ exercises its fibrotic action through induction of the SK1/S1P axis. Furthermore, the PDGF growth factor, positive regulator of proliferation and motility, activates the enzyme SK1 and the transactivation of S1P1 inhibits the proliferation and induces the migration induced by the growth factor. Finally, the mitogenic role of C1P in myoblasts has been identified, characterizing the signalling pathways involved.
dc.languageItalian
dc.relation.ispartofseriesPremio Tesi di Dottorato
dc.rightsopen access
dc.subject.classificationthema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciencesen_US
dc.subject.classificationthema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistryen_US
dc.subject.classificationthema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biologyen_US
dc.titleSfingolipidi bioattivi e loro ruolo nell'azione biologica di fattori di crescita e citochine
dc.typebook
oapen.identifier.doi10.36253/978-88-6655-219-2
oapen.relation.isPublishedBy2ec4474d-93b1-4cfa-b313-9c6019b51b1a
oapen.relation.isbn9788866552192
oapen.relation.isbn9788866552185
oapen.relation.isbn9788892735644
oapen.pages152
oapen.place.publicationFirenze
dc.seriesnumber26
dc.abstractotherlanguageThis book gives an analysis of the role of the bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide 1-phosphate (C1P) in the skeletal muscle. The enzyme that produces S1P, sphingosine kinase 1 (SK1) has proved crucial in the biological action of growth factors and cytokines involved in the inflammatory process that follows muscular damage. Indeed, in myoblasts the cytokine TGFβ exercises its fibrotic action through induction of the SK1/S1P axis. Furthermore, the PDGF growth factor, positive regulator of proliferation and motility, activates the enzyme SK1 and the transactivation of S1P1 inhibits the proliferation and induces the migration induced by the growth factor. Finally, the mitogenic role of C1P in myoblasts has been identified, characterizing the signalling pathways involved.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

open access
Except where otherwise noted, this item's license is described as open access