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dc.contributor.editorTzanakakis, George
dc.contributor.editorNikitovic, Dragana
dc.date.accessioned2022-05-06T11:32:08Z
dc.date.available2022-05-06T11:32:08Z
dc.date.issued2022
dc.identifierONIX_20220506_9783036534053_225
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/81159
dc.description.abstractThe extracellular matrix (ECM) scaffold, which surrounds and supports the cells in tissues, consists of fibrillar proteins, proteoglycans, glycosaminoglycans, signaling molecules, and enzymes involved in its remodeling. The stages of cancer progression, e.g., local invasion, intravasation, extravasation, distant invasion and immunosuppression, are obligatorily perpetrated through interactions of these tumor cells with the ECM. Cancer-related ECM changes can be exploited for the evaluation of disease progression, anticancer therapy development, and monitoring of therapy response. Thus, in breast cancer, hyaluronan-mediated wound repair mechanisms are hijacked to promote tumor development. Altered mechanical properties of the pancreatic cancer ECM are immunosuppressive and prevent the penetration of cytotoxic chemotherapy agents. The expression of the proteoglycan syndecan-4 is modulated by anticancer drugs, suggesting its potential druggabilty capacity. Another proteoglycan, lumican, is proposed as a cancer prognosis marker, chemoresistance regulator, and cancer therapy target. Due to their remodeling properties, the MMPs are vital mediators and important therapeutic targets. Treatment of breast cancer cells with sulfated hyaluronan has been shown to attenuate tumor cell growth, migration, and invasion. Extracellular vesicles (EVs), comprising exosomes, microvesicles, and apoptotic bodies, are released by all cells into the ECM and body fluids and can be utilized as diagnostic markers in malignant pleural mesothelioma. These exciting developments encourage tumor biology scientists for further creative research.
dc.languageEnglish
dc.subject.classificationthema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: generalen_US
dc.subject.otherelastin
dc.subject.otherribosomal protein SA
dc.subject.othertongue carcinoma
dc.subject.otherMMP-2
dc.subject.otherEGCG
dc.subject.otherpancreatic ductal adenocarcinoma
dc.subject.othersyndecans
dc.subject.otherproteoglycans
dc.subject.othertumor progression
dc.subject.otherangiogenesis
dc.subject.othersyndecan-4
dc.subject.otherheparan sulfate
dc.subject.othercancer
dc.subject.otherprognosis
dc.subject.otherbiomarker
dc.subject.othersignal transduction
dc.subject.otherproteoglycan
dc.subject.othermetastasis
dc.subject.otherextracellular matrix
dc.subject.otherfibrosis
dc.subject.otherimmune cell modulation
dc.subject.otherneutrophils
dc.subject.otherneutrophil extracellular trap
dc.subject.othermacrophages
dc.subject.otherBCC
dc.subject.otherMMP
dc.subject.otherTIMP
dc.subject.otherinvasion
dc.subject.otherlumican
dc.subject.othercancer cell growth
dc.subject.othermotility
dc.subject.otherhyaluronan
dc.subject.otherRHAMM
dc.subject.otherCD44
dc.subject.otherwound repair
dc.subject.otherbreast cancer
dc.subject.othermalignant pleural mesothelioma
dc.subject.otherpleural effusion
dc.subject.otherextracellular vesicles
dc.subject.otherbiomarkers
dc.subject.othersulfated hyaluronan
dc.subject.otherestrogen receptors
dc.subject.otherepithelial-to-mesenchymal transition
dc.subject.othermatrix metalloproteinases
dc.subject.othern/a
dc.titleThe Role of Extracellular Matrix in Cancer Development and Progression
dc.typebook
oapen.identifier.doi10.3390/books978-3-0365-3406-0
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn9783036534053
oapen.relation.isbn9783036534060
oapen.pages182
oapen.place.publicationBasel


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