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dc.contributor.editorFalguières, Thomas
dc.date.accessioned2022-05-06T11:23:58Z
dc.date.available2022-05-06T11:23:58Z
dc.date.issued2022
dc.identifierONIX_20220506_9783036539447_107
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/81041
dc.description.abstractMammalian ATP-binding cassette (ABC) transporters constitute a superfamily of proteins involved in many essential cellular processes. Most of these transporters are transmembrane proteins and allow the active transport of solutes, small molecules, and lipids across biological membranes. On the one hand, some of these transporters are involved in drug resistance (also referred to as MDR or multidrug resistance), a process known to be a major brake in most anticancer treatments, and the medical challenge is thus to specifically inhibit their function. On the other hand, molecular defects in some of these ABC transporters are correlated with several rare human diseases, the most well-documented of which being cystic fibrosis, which is caused by genetic variations in ABCC7/CFTR (cystic fibrosis transmembrane conductance regulator). In the latter case, the goal is to rescue the function of the deficient transporters using various means, such as targeted pharmacotherapies and cell or gene therapy. The aim of this Special Issue, “ABC Transporters in Human Diseases”, is to present, through original articles and reviews, the state-of-the-art of our current knowledge about the role of ABC transporters in human diseases and the proposed therapeutic options based on studies ranging from cell and animal models to patients.
dc.languageEnglish
dc.subject.classificationthema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: generalen_US
dc.subject.classificationthema EDItEUR::P Mathematics and Science::PS Biology, life sciencesen_US
dc.subject.otherABC transporters
dc.subject.otherdrug action
dc.subject.otherregulatory extension
dc.subject.otherregulatory insertion
dc.subject.othermechanism of action
dc.subject.otherMRP1
dc.subject.otherMRP4
dc.subject.otherbreast cancer
dc.subject.otherproliferation
dc.subject.othermigration
dc.subject.otherinvasion
dc.subject.othercAMP
dc.subject.otherABCG2
dc.subject.otherABCB1
dc.subject.otherblood-brain barrier
dc.subject.otherPET
dc.subject.otherAlzheimer’s disease
dc.subject.otherbeta-amyloid
dc.subject.othertariquidar
dc.subject.othererlotinib
dc.subject.otherABCG5
dc.subject.otherABCG8
dc.subject.otherATP-binding cassette transporter
dc.subject.othercholesterol
dc.subject.otherpolar relay
dc.subject.othersitosterolemia
dc.subject.other5′ untranslated region
dc.subject.othercis-acting elements
dc.subject.otherABCA subfamily
dc.subject.otherbioinformatics
dc.subject.otherABC transporter
dc.subject.othertherapy response
dc.subject.otherdisease-free survival
dc.subject.othernext-generation sequencing
dc.subject.othercompetitive allele-specific PCR
dc.subject.otherP-glycoprotein
dc.subject.otheramyloid-beta
dc.subject.otherneuron
dc.subject.otherSK-N-SH
dc.subject.othergene therapy
dc.subject.otherAAV
dc.subject.otherPFIC
dc.subject.otherBSEP
dc.subject.otherABCB11
dc.subject.otherbile salts
dc.subject.otherintrahepatic cholestasis
dc.subject.otherchaperones
dc.subject.otherPFIC2
dc.subject.otherBRIC
dc.subject.otherATP-binding cassette transporter A1 (ABCA1)
dc.subject.othercholesterol homeostasis
dc.subject.otherreverse cholesterol transport
dc.subject.otherHDL-C
dc.subject.otherdyslipidemia
dc.subject.othertype 2 diabetes
dc.subject.othermicroparticles
dc.subject.otherABCG2 genotype
dc.subject.otherclinico-genetic analysis
dc.subject.otherethnic specificity
dc.subject.othergenetic variations
dc.subject.otherprecision medicine
dc.subject.otherrare variant
dc.subject.otherRoma
dc.subject.otherserum uric acid
dc.subject.otherSUA-lowering therapy
dc.subject.otherurate transporter
dc.subject.otherbile secretion
dc.subject.otherABCB4
dc.subject.otherABCC2
dc.subject.otherABCG5/G8
dc.subject.othermolecular partners
dc.subject.otherphytosterol
dc.subject.otherxenosterol
dc.subject.otheratherosclerosis
dc.subject.othergall stone
dc.subject.otherABC
dc.subject.othertransporter
dc.subject.otherABC (ATP-binding cassette) transporters
dc.subject.othermultidrug resistance
dc.subject.othertransport
dc.subject.othertrafficking
dc.subject.otherurate
dc.subject.othermutations
dc.subject.otherpolymorphisms
dc.subject.otherABCC6
dc.subject.otherTNAP
dc.subject.otherNT5E
dc.subject.otherPseudoxanthoma elasticum (PXE)
dc.subject.othercancer
dc.subject.othermembrane protein
dc.subject.otherfunctional divergence
dc.subject.othercalcification
dc.subject.otherpseudoxanthoma elasticum
dc.subject.othergeneralized arterial calcification of infancy
dc.subject.otherpyrophosphate
dc.subject.othertherapies
dc.subject.otherABCA7
dc.subject.otherphagocytosis
dc.subject.otherAβ peptides
dc.subject.otheryeast
dc.subject.othermultidrug transporter
dc.subject.otheranticancer
dc.subject.otherantifungal resistance
dc.subject.othermechanism
dc.subject.otherperoxisome
dc.subject.otheradrenoleukodystrophy
dc.subject.otherfatty acids
dc.subject.othergout
dc.subject.otherearly-onset gout
dc.subject.otherhyperuricemia
dc.subject.otheruric acid
dc.subject.otherBCRP
dc.subject.othersingle nucleotide polymorphism
dc.subject.otherSNP
dc.subject.otherhomology modeling
dc.subject.othersubstrate-binding site
dc.subject.othercellular ATP efflux
dc.subject.othermutagenesis
dc.subject.otherintracellular traffic
dc.subject.otherMDR3
dc.subject.otherphosphatidylcholine
dc.subject.otherRAB GTPase
dc.subject.othertaxol
dc.subject.otherdrug transport
dc.subject.othern/a
dc.titleABC Transporters in Human Diseases
dc.typebook
oapen.identifier.doi10.3390/books978-3-0365-3943-0
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn9783036539447
oapen.relation.isbn9783036539430
oapen.pages494
oapen.place.publicationBasel


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