Show simple item record

dc.contributor.editorMaccarrone, Mauro
dc.date.accessioned2022-05-06T11:22:42Z
dc.date.available2022-05-06T11:22:42Z
dc.date.issued2022
dc.identifierONIX_20220506_9783036530062_96
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/81030
dc.description.abstractDuring the last 60 years the relevance of cannabis (Cannabis sativa or Cannabis indica) ingredients, like the psychoactive Δ9-tetrahydrocannabinol (THC), cannabidiol, 120+ additional cannabinoids and 440+ non-cannabinoid compounds, for human health and disease has become apparent. Approximately 30 years after the elucidation of THC structure the molecular reasons for the biological activity of these plant extracts were made clearer by the discovery of endocannabinoids, that are endogenous lipids able to bind to the same receptors activated by THC. Besides endocannabinoids, that include several N-acylethanolamines and acylesters, a complex array of receptors, metabolic enzymes, transporters (transmembrane, intracellular and extracellular carriers) were also discovered, and altogether they form a so-called “endocannabinoid system” that has been shown to finely tune the manifold biological activities of these lipid signals. Both plant-derived cannabinoids and endocannabinoids were first discovered by the group led by Prof. Dr. Raphael Mechoulam, who has just celebrated his 90th birthday and clearly stood out as a giant of modern science. The many implications of his seminal work for chemistry, biochemistry, biology, pharmacology and medicine are described in this special issue by the scientists who reached during the last 20 years the highest recognition in the field of (endo)cannabinoid research, receiving the Mechoulam Award for their major contributions. I thank them for having accepted my invitation to be part of this honorary issue of Molecules, and Raphi for continuing to illuminate our field with his always inspiring investigations and new ideas.
dc.languageEnglish
dc.subject.classificationbic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
dc.subject.classificationbic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
dc.subject.classificationbic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSB Biochemistry
dc.subject.othercannabinoid
dc.subject.otherMRI-1867
dc.subject.otherhybrid ligand
dc.subject.otherCB1 receptor antagonist
dc.subject.otheriNOS inhibitor
dc.subject.otherrimonabant
dc.subject.otherintracerebroventricular administration
dc.subject.otheralcohol craving
dc.subject.othertwo-bottle paradigm
dc.subject.otherdrinking in the dark
dc.subject.otherN-acyltransferase
dc.subject.otheranandamide
dc.subject.otherendocannabinoid
dc.subject.otherphospholipase A2
dc.subject.othercannabichromene
dc.subject.othercannabidiolic acid
dc.subject.othercannabidivarin
dc.subject.othercannabidivarinic acid
dc.subject.otherphytocannabinoids
dc.subject.othertetrahydrocannabivarin
dc.subject.other4′-fluoro-cannabidiol
dc.subject.othercannabinoid tetrad
dc.subject.otherelevated plus maze
dc.subject.othercatalepsy
dc.subject.othermarble bury
dc.subject.otherHUF-101
dc.subject.otherequilibrative nucleoside transporter
dc.subject.otherCB1
dc.subject.otherbiased signaling
dc.subject.otherfunctional selectivity
dc.subject.otherG-protein
dc.subject.otherβ-arrestin
dc.subject.othercannabigerol
dc.subject.otheranti-inflammatory
dc.subject.otherobesity
dc.subject.othercannabinoid receptor 2 (CB2R)
dc.subject.othermicroglia
dc.subject.otherinflammaging
dc.subject.othermemory
dc.subject.otherlipofuscin
dc.subject.otheraminoalkylindole
dc.subject.otherallodynia
dc.subject.otherantinociception
dc.subject.othercannabinoid receptor
dc.subject.otherCP55940
dc.subject.otherJWH-018
dc.subject.otherK2
dc.subject.otherpravadoline
dc.subject.otherspice
dc.subject.otherWIN55212-2
dc.subject.othertype 1 cannabinoid receptor CB1
dc.subject.othercholesterol
dc.subject.otherhippocampus
dc.subject.otherfrontal cortex
dc.subject.othersynaptosomes
dc.subject.otherrescue model
dc.subject.otheranti-CB1 antibody
dc.subject.othercannabinoids
dc.subject.otherGPR55 receptors
dc.subject.otherVCE-006.1
dc.subject.otherchromenopyrazole
dc.subject.otherParkinson’s disease
dc.subject.other6-hydroxydopamine
dc.subject.otherlipopolysaccharide
dc.subject.otheramyotrophic lateral sclerosis
dc.subject.othermSOD1 mice
dc.subject.otherTDP-43 transgenic mice
dc.subject.otherPPARs
dc.subject.othergut microbiome
dc.subject.otherintestine
dc.subject.otherghrelin
dc.subject.otherLEAP2
dc.subject.othern/a
dc.titleA Themed Issue in Honor of Professor Raphael Mechoulam: The Father of Cannabinoid and Endocannabinoid Research
dc.typebook
oapen.identifier.doi10.3390/books978-3-0365-3007-9
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn9783036530062
oapen.relation.isbn9783036530079
oapen.pages236
oapen.place.publicationBasel


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

https://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/