Cancer Biomarker Research and Personalized Medicine
Meehan, James (editor)
Biomarkers are measures of a biological state. The treatment of individual patients based on particular factors, such as biomarkers, distinguishes standard, generalized treatment plans from personalized medicine. Even though personalized medicine is applicable to most branches of medicine, the field of oncology is perhaps where it is most easily employed. Cancer is a heterogeneous disease; although patients may be diagnosed histologically with the same cancer type, their tumors can comprise varying tumor microenvironments and molecular characteristics that can impact treatment response and prognosis. There has been a major drive over the past decade to try and realize personalized cancer medicine through the discovery and use of disease-specific biomarkers. This book, entitled “Cancer Biomarker Research and Personalized Medicine”, encompasses 22 publications from colleagues working on a diverse range of cancers, including prostate, breast, ovarian, head and neck, liver, gastric, bladder, colorectal, and kidney. The biomarkers assessed in these studies include genes, intracellular or secreted proteins, exosomes, DNA, RNA, miRNA, circulating tumor cells, circulating immune cells, in addition to radiomic features.
Keywordsclear cell renal cell carcinoma; radiomics; WHO/ISUP nuclear grade; multiphasic multidetector computed tomography; triple-negative breast cancer; taxane; chemotherapy; GBP5; Akt/mTOR; autophagy; IL13Rα2; renal cell carcinoma; JAK2; FOXO3; telmisartan; ovarian cancer; bioinformatics; CREB1; drug perturbation; lincRNA-p21; rectal cancer; chemoradiotherapy; colorectal cancer; long non-coding RNA; p53; predictive biomarker; intestinal anastomosis; anastomotic leak; biomarkers; precision medicine; personalized medicine; biomarker; AmpliSeq; DNA methylation; epigenetics; head and neck cancer; saliva; liquid biopsy; meta-analysis; gastric cancer; middle-up-down; haptoglobin; glycopeptide; mass spectrometry; circulating tumor cells; prostate cancer; cancer vaccine; immune response; breast cancer; predictive tools; prognostic tools; translational research; IL6ST; gp130; cytokine signalling; tissue-based biomarkers; liquid-based biomarkers; radiotherapy; radiosensitivity biomarkers; secretome; radioresistance; bladder tumor; lymphocyte-to-monocyte ratio; peripheral blood parameters; tumor recurrence; transurethral resection; lipidomics; 1H-NMR; LC-MS/MS; lipoprotein subfractions; lipoprotein lipase; cancer biomarkers; hepatocellular carcinoma; p16 expression; head and neck squamous cell carcinoma; HPV genotyping; exosomes; chemoresistance; comparative oncology; One Health; microRNA; lymph node metastasis; hormone-dependent carcinogenesis; localized prostate cancer; prognostic factors; HNSCC; n/a
Webshop linkhttps://mdpi.com/books/pdfview ...
Publication date and placeBasel, 2022