Special Issue in Honor of Professor James D. McChesney on the Occasion of his 80th Birthday
Ilias, Muhammad (editor)
Nanayakkara, Dhammika (editor)
Plants have been the sources of important pharmaceuticals, flavoring agents, and agrochemicals. The antimalarial drugs artemisinin and quinine; the anticancer drugs taxol, etoposide, and vinca alkaloids; the sugar-free sweetening agents stevioside and rebaudiosides; and antifeedant azadiractin are good examples of important plant-based drugs, food additives, and agrochemicals currently on the market. Despite these and many other successes, there are significant challenges to discovering and developing commercially important natural products from plants, such as procuring plant materials in large quantities, separating active constituents from complex mixtures, and undesirable qualities, such as low solubility or poor chemical or metabolic stability of active constituents. Dr. James D. McChesney has contributed immensely to overcoming the inherent challenges associated with discovering and developing products modeled from plant-based natural product leads. His research on artemisinin, taxol, galanthamine, podophyllotoxin, and stevia sweet glycosides exemplifies the magnitude of these contributions. His extensive work on the structural modification of taxol led to the discovery and development of the anticancer agent TPI 287, a third-generation taxane analog that is currently undergoing clinical trials. Dr. McChesney has had a long, distinguished teaching and research career, has authored more than 225 research publications, and holds more than 60 patents. He is a past president and Fellow of the American Society of Pharmacognosy and a Fellow of the AAAS. He has mentored many graduate students, post-docs, and junior faculty members who hold prominent positions in natural products research establishments in the US and worldwide. We wish to dedicate this Special Issue Book Version to celebrate the eightieth birthday of Dr. McChesney, a prolific thinker with abundant inventiveness in the field of natural product chemistry and pharmacognosy.
KeywordsMagnoliaceae; GC-FID; GC-MS; mosquito control; 1-decanol; 1-octanol; larvicidal activity; deterrent; biopesticides; Persea americana Mill.; avocado oil; triglyceride; fatty acid; UHPLC/ESI-MS; GC/MS; quality evaluation; Calu-3 cell line; cancer chemotherapy; drug resistance; poly(ε-caprolactone); poly(ethylene glycol); isoflavonoids; polyisoprenylated benzophenones; propolis; botanical sources; oxyresveratrol; Artocarpus lakoocha; DNA damaging; pro-oxidant; medicinal plants; cancer; Ethiopia; phytochemistry; endophytic fungus; Teratosphaeria; teratopyrones; naphtho-γ-pyrones; nigerasperone A; recombinant monoamine oxidase-A; monoamine oxidase-B; neurological disorder; enzyme kinetics; molecular docking; inhibition activity; flavonoid; Atractylodes macrocephala; wheat bran; processing; NMR; atractylon derivatives; isolation and identification; Machaerium Rimachi 12161; machaerifurogerol; 5-epi-machaerifurogerol; machaeriol A–C; machaeridiol A–C; isoflavonoid; MRSA; VRE; gram negative bacteria; Torreya taxifolia; plant pathogenic fungi; Botryosphaeria dothidea; malaria; phytotoxin; γ-lactam alkaloids; Momordica charantia; cucurbitane-type triterpene glycosides; charantoside XV; α-amylase; α-glucosidase; anti-inflammatory activity; in silico study; in vitro propagation; medicinal crops; phytomedicines; Stevia rebaudiana; HPTLC; HPLC methods; mass spectrometry dissociation pattern; endocyclic and exocyclic diterpene glycosides; scale up; UHPLC/Q-TOF-MS analysis; glycerin; process contaminants; 3-monochloropropane-1,2-diol esters; glycidyl esters; glycyrrhizin; SARS-CoV-2; surface plasmon resonance; autodocking; n/a
Webshop linkhttps://mdpi.com/books/pdfview ...
Publication date and placeBasel, 2022
Research & information: general
Biology, life sciences