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dc.contributor.editorBarresi, Valeria
dc.date.accessioned2022-02-24T10:35:13Z
dc.date.available2022-02-24T10:35:13Z
dc.date.issued2022
dc.identifierONIX_20220224_9783036529233_47
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/78749
dc.description.abstractColorectal cancer is one of the most common malignancies worldwide, and the pathogenesis of this neoplasm is probably one of the most studied. The knowledge obtained over time has led to the development of screening and early diagnosis systems, allowing a significant reduction in the incidence of this neoplasm. However, what is currently known probably represents only the tip of the iceberg of the biology of this tumor. It was recently shown that the gut microbiota may contribute to colorectal cancerogenesis. In addition, several novel targeted therapies are now applied to patients with colorectal carcinoma. Nonetheless, several questions are still unanswered. Could the modulation of the gut microbiota modify the risk of tumor progression or the efficacy of therapies? Are there any predictive biomarkers of the risk of tumor progression or the efficacy of target therapies? Is metastatic colorectal cancer one or more diseases? This book collects a series of scientific articles reflecting part of the state of the art regarding colorectal cancer, seeking to answer these questions.
dc.languageEnglish
dc.subject.classificationthema EDItEUR::M Medicine and Nursingen_US
dc.subject.otherMSH2 3’UTR variant
dc.subject.otherhereditary colon cancer
dc.subject.otherLynch syndrome
dc.subject.otherMSH2 protein
dc.subject.otherover expression MSH2
dc.subject.otherMMR gene
dc.subject.otherMMR complex deficiency
dc.subject.otherMSH2 unclassified variants
dc.subject.otherliquid biopsy
dc.subject.othercolorectal cancer
dc.subject.otherbiomarkers
dc.subject.othercirculating tumor cells
dc.subject.othercirculating tumor DNA
dc.subject.othergenomic alterations
dc.subject.othermetastasis
dc.subject.othertumor heterogeneity
dc.subject.othertumor evolution
dc.subject.otherADAM17
dc.subject.othercolorectal cancer (CRC)
dc.subject.otherTNFα
dc.subject.otherIL-6R
dc.subject.otherAREG
dc.subject.othershedding
dc.subject.otherregularized optimization
dc.subject.otherCox regression
dc.subject.othersurvival analysis
dc.subject.otherTCGA data
dc.subject.otherRNA-seq data
dc.subject.othergut microbiota
dc.subject.othercolorectal adenoma
dc.subject.otherpolyps
dc.subject.otherbacteria
dc.subject.othermonoclonal antibody
dc.subject.othertherapeutic target
dc.subject.othertherapy
dc.subject.othercolon cancer
dc.subject.otherpoorly differentiated clusters
dc.subject.otherprognostic factors
dc.subject.otherinflammatory markers
dc.subject.otherhistopathological markers
dc.subject.otherimmune system
dc.subject.othercolorectal surgery
dc.subject.othernanofibrous materials
dc.subject.otheranastomotic leakage
dc.subject.otherintestinal anastomosis
dc.subject.otheranastomotic patch
dc.subject.otherpolycaprolactone
dc.subject.otherelectrospinning
dc.subject.otherexperiment
dc.subject.otherperitoneal adhesions
dc.subject.otherCRC
dc.subject.otherCTC
dc.subject.otherctDNA
dc.subject.othermi-RNA
dc.subject.othernc-RNA
dc.subject.otherdifferentially expressed genes
dc.subject.othercancer stem cells
dc.subject.otherqPCR
dc.subject.otherchemoresistance
dc.subject.otherTRIM8
dc.subject.othermiR-17-5p
dc.subject.otherPDX
dc.subject.otherpatient-derived xenograft
dc.subject.otheromega-3 fatty acids
dc.subject.othern/a
dc.titleColorectal Cancer
dc.title.alternativeFrom Pathophysiology to Novel Therapeutic Approaches
dc.typebook
oapen.identifier.doi10.3390/books978-3-0365-2923-3
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn9783036529233
oapen.relation.isbn9783036529226
oapen.pages284
oapen.place.publicationBasel


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