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dc.contributor.editorDiebold, Yolanda
dc.contributor.editorGarcía-Posadas, Laura
dc.date.accessioned2022-01-11T13:53:06Z
dc.date.available2022-01-11T13:53:06Z
dc.date.issued2021
dc.identifierONIX_20220111_9783036526119_959
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/77128
dc.description.abstractThe concept of advanced therapy medicinal products (ATMPs) encompasses novel kinds of medicines for human use that are based on genes, cells or tissues. These intend to offer not only regeneration, but complete functional recovery of diseased tissues and organs using different strategies. Gene therapy, cell therapy and tissue engineering are the main areas in which promising advanced therapies are emerging. The eye is a very complex organ whose main structures, the cornea and the retina, play a pivotal role in maintaining normal vision, as severe alterations in these tissues can lead to blindness. Ocular tissues are starting to benefit from ATMPs by fighting against the enormous complexity and devastating potential of many ocular diseases. However, developments arising from this field of work face important challenges related to vectors to deliver drugs and genetic material to target tissues, suitable biomaterials to prepare cell scaffolds and cell stemness, among others—not to mention the complicated legislation around ATMPs, the complexity in production and quality control and the absence of standardized protocols.The purpose of this Special Issue is to serve as an overview of the current progress in the application of cell and gene therapies, as well as tissue engineering to restore functionality in diseased ocular structures, and the challenges linked to reaching patients.
dc.languageEnglish
dc.subject.classificationthema EDItEUR::M Medicine and Nursingen_US
dc.subject.otherMPC polymer
dc.subject.otherdry eye
dc.subject.otherocular surface
dc.subject.otherlacrimal fluid
dc.subject.othermucin
dc.subject.other3D bioprinting
dc.subject.othercornea
dc.subject.otherretina
dc.subject.otherophthalmology
dc.subject.othertissue regeneration
dc.subject.otherelectrospinning
dc.subject.otherconjunctiva
dc.subject.otherdecellularized tissue matrix
dc.subject.othersmall intestinal submucosa
dc.subject.otherurinary bladder matrix
dc.subject.otherpolycaprolactone
dc.subject.otherfiber
dc.subject.othertissue engineering
dc.subject.otherstratification
dc.subject.otherconjunctival epithelial cells
dc.subject.otherhydrogel
dc.subject.otherkeratoplasty
dc.subject.otherscaffold
dc.subject.othercollagen
dc.subject.otheradvanced therapy medicinal product
dc.subject.otherATMP
dc.subject.othercell therapy
dc.subject.othergene therapy
dc.subject.othereye
dc.subject.otherocular
dc.subject.otherregulatory
dc.subject.othermarketing authorization
dc.subject.otherdouble-crosslinking
dc.subject.othercarbodiimide
dc.subject.otherglutaraldehyde
dc.subject.othersodium metabisulfite
dc.subject.othersodium borohydride
dc.subject.otherEDC/NHS
dc.subject.otherstem cells
dc.subject.otherretinal diseases
dc.subject.otheroptic nerve diseases
dc.subject.othercell replacement
dc.subject.othercell sources
dc.subject.otheradvanced therapies
dc.subject.otherocular mucosa
dc.subject.otherblindness
dc.subject.otherCLET
dc.subject.otherlimbal niche
dc.subject.otherlimbal stem cell
dc.subject.otherLSCD
dc.subject.othermesenchymal stem cell transplantation
dc.subject.otherMSCT
dc.subject.othercorneal limbus
dc.subject.otherdecellularized xenograft
dc.subject.otherrecellularization
dc.subject.othermesenchymal stem cells
dc.subject.othern/a
dc.titleAdvanced Therapy Medicinal Products for Eye Diseases: Goals and Challenges
dc.typebook
oapen.identifier.doi10.3390/books978-3-0365-2610-2
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isFundedBy7224c55a-d5e7-455a-a8c7-fed603648816
oapen.relation.isbn9783036526119
oapen.relation.isbn9783036526102
oapen.pages207
oapen.place.publicationBasel, Switzerland
oapen.grant.number[grantnumber unknown]


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