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dc.contributor.editorBruni, Francesco
dc.date.accessioned2022-01-11T13:47:31Z
dc.date.available2022-01-11T13:47:31Z
dc.date.issued2021
dc.identifierONIX_20220111_9783036521510_786
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/76954
dc.description.abstractMitochondria play an increasingly central role in the context of cellular physiology. These organelles possess their own genome (mtDNA), which is functionally coordinated with the nuclear genome. Mitochondrial gene expression is mediated by molecular processes (replication, transcription, translation, and assembly of respiratory chain complexes) that all take place within the mitochondria. Several aspects of mtDNA expression have already been well characterized, but many more either are under debate or have yet to be discovered. Understanding the molecular processes occurring in mitochondria also has clinical relevance. Dysfunctions affecting these important metabolic ‘hubs’ are associated with a whole range of severe disorders, known as mitochondrial diseases. In recent years, significant progress has been made to understand the pathogenic mechanisms underlying mitochondrial dysfunction; however, to date, mitochondrial diseases are complex genetic disorders without any effective therapy. Current therapeutic strategies and clinical trials are aimed at mitigating clinical manifestations and slowing the disease progression to improve the quality of life of patients. The goal of the Special Issue ‘Mitochondria: from Physiology to Pathology’ published in Life (ISSN: 2075-1729) was to collect research and review articles covering the physiological and pathological aspects related to mtDNA maintenance and gene expression, mitochondrial biogenesis, protein import, organelle metabolism, and quality control.
dc.languageEnglish
dc.subject.classificationbic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
dc.subject.otheratherosclerosis
dc.subject.othercarotid intima-media thickness
dc.subject.othermitochondrial mutations
dc.subject.othercardiovascular risk factors
dc.subject.othermitochondria
dc.subject.othermtDNA
dc.subject.othercristae
dc.subject.othermitochondrial fission
dc.subject.othermitochondrial fusion
dc.subject.othermitochondrial diseas
dc.subject.othermitochondrial dynamics
dc.subject.othermitoenergetics
dc.subject.othermitosteroidogenesis
dc.subject.otherLH
dc.subject.othercAMP
dc.subject.otherLeydig cell
dc.subject.othermitochondrial DNA segregation
dc.subject.otherheteroplasmy
dc.subject.otherselective elimination
dc.subject.othermitophagy
dc.subject.othermitochondrial engineered nucleases
dc.subject.otherkinases
dc.subject.otherphosphorylation
dc.subject.otherdisease
dc.subject.otherPINK1
dc.subject.otherParkinson’s disease
dc.subject.othermitochondria homeostasis
dc.subject.otherCterm
dc.subject.otherMELAS
dc.subject.othertransmitochondrial cybrids
dc.subject.otheraminoacyl-tRNA synthetases
dc.subject.otherLARS2
dc.subject.othermitochondrial disease
dc.subject.othertherapeutic peptides
dc.subject.otherFAD synthase
dc.subject.otherFAD1
dc.subject.othermitochondria localization
dc.subject.otherSaccharomyces cerevisiae
dc.subject.othermRNA
dc.subject.othermitochondrial localization motif
dc.subject.othern/a
dc.titleMitochondria: From Physiology to Pathology
dc.typebook
oapen.identifier.doi10.3390/books978-3-0365-2152-7
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn9783036521510
oapen.relation.isbn9783036521527
oapen.pages196
oapen.place.publicationBasel, Switzerland


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