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dc.contributor.editorKorinek, Vladimir
dc.date.accessioned2022-01-11T13:42:50Z
dc.date.available2022-01-11T13:42:50Z
dc.date.issued2021
dc.identifierONIX_20220111_9783036512761_543
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/76808
dc.description.abstractDear Readers, Understanding the pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share a similar genetic, physiological and behavioural composition. The ancient Greeks were the first to use animals as models for anatomy and physiology, and this was consequently adopted by other cultures and led to important discoveries. In recent years, there have been many efforts to understand and fight cancer through new revolutionary personalized treatments and wider screenings that help diagnose and treat cancer. A fundamental part of this effort is to develop suitable cancer animal models that simulate the different disease variants and their progression. Ranging from tumor-derived xenografts to genetically engineered models, a wide variety of systems are applied for this purpose, and many technological breakthroughs are changing the way cancer is studied and analyzed. In this Special Issue, we collected a set of research articles and reviews that focus on the generation of cancer animal models that are used for understanding the disease and contribute to designing and testing new drugs for cancer prevention or treatment. Vladimir Korinek Collection Editor
dc.languageEnglish
dc.subject.classificationthema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: generalen_US
dc.subject.classificationthema EDItEUR::P Mathematics and Science::PS Biology, life sciencesen_US
dc.subject.othersoy
dc.subject.otherisoflavones
dc.subject.othermammary tumor prevention
dc.subject.otherrodent models
dc.subject.otherchemical carcinogens
dc.subject.othertransgenic mice
dc.subject.otherZebrafish
dc.subject.otherDrosophila
dc.subject.otherrats
dc.subject.othermice
dc.subject.otherNPM-1
dc.subject.otherFLT3 ITD
dc.subject.otherETO-1
dc.subject.otherIDH1/2
dc.subject.otherneural stem cells
dc.subject.otherbrain and nervous system cancers
dc.subject.otherneurogenic niches
dc.subject.otherradiotherapy
dc.subject.othersparing of neurogenic regions
dc.subject.othercarcinoma
dc.subject.otherconsensus molecular subtypes
dc.subject.otherintestine
dc.subject.otheroncogenes
dc.subject.othersignaling cascades
dc.subject.othertumor suppressors
dc.subject.othertumorigenesis
dc.subject.otherMPN (myeloproliferative neoplasms)
dc.subject.otherzebrafish
dc.subject.otheriPSCs
dc.subject.otherJAK2
dc.subject.otherMPL
dc.subject.otherCALR
dc.subject.otherthrombosis
dc.subject.otherubiquitin–proteasome system
dc.subject.othercancer
dc.subject.othermouse model
dc.subject.othergene inactivation
dc.subject.othercolorectal cancer
dc.subject.othermouse models
dc.subject.othermicrobiota
dc.subject.otherantitumor immunity
dc.subject.othermelanoma
dc.subject.othermutation
dc.subject.othergenetics
dc.subject.otheranimal model
dc.subject.otherswine
dc.subject.otherMeLiM
dc.subject.otherprogression
dc.subject.otherspontaneous regression
dc.subject.otherdevitalization
dc.subject.othermetaplasia
dc.subject.otherCdx
dc.subject.otheranimal models
dc.subject.otherepigenetics
dc.subject.otherxenotransplantation
dc.subject.otherdrug screen
dc.subject.otherpre-clinical cancer model
dc.subject.othernon-mouse models
dc.subject.othergene editing
dc.subject.otherstem cells
dc.subject.othersolid tumors
dc.subject.otherhematologic malignancies
dc.titleAnimal Modeling in Cancer
dc.typebook
oapen.identifier.doi10.3390/books978-3-0365-1277-8
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn9783036512761
oapen.relation.isbn9783036512778
oapen.pages273
oapen.place.publicationBasel, Switzerland


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