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dc.contributor.editorTrikha, Prashant
dc.contributor.editorThakar, Monica
dc.contributor.editorRussell Cruz, Conrad
dc.date.accessioned2021-11-18T16:23:13Z
dc.date.available2021-11-18T16:23:13Z
dc.date.issued2020
dc.identifierONIX_20211118_9782889635641_848
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/73716
dc.description.abstractCell-based immunotherapy is based on the seemingly simple principle of harnessing the power of the immune system to combat cancer, and is emerging as an important clinical tool. The remarkable success of CAR-T cell therapies demonstrate that cell based therapies are effective at eradicating hematological malignancies, and therefore hold great promise for other cancers. However, there are number of challenges that limit the full potential of cell based therapies, especially for solid cancers. T cells and NK cells represent major lymphocyte populations that are involved in immune surveillance and tumor eradication, and both are emerging as important players for cell based immunotherapy. Although they use different mechanisms for recognizing cancer cells, they complement each other during tumor eradication. NK cells have many functional similarities to T cells and represent the closest innate immune cell lineage to adaptive immune cell populations. Transcriptome analysis has also revealed similar phylogenetic origin of the two lymphocyte populations. The hurdles that impact therapeutic success of these cells include trafficking of lymphocytes to the tumor sites, recognition of solid tumors, and overcoming the inhospitable tumor microenvironment (TME) including the presence of suppressive cells (Treg and MDSC) and immune suppressive cytokines (TGFβ). The full potential of cell based therapies may be realized once tools to overcome these barriers are developed. This Research Topic collects articles critically examining these obstacles and the novel strategies being developed for cell-based therapies to overcome them.
dc.languageEnglish
dc.subject.classificationbic Book Industry Communication::M Medicine
dc.subject.classificationbic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
dc.subject.otherimmunotherapy
dc.subject.otherNK cell
dc.subject.othertumor micoenvironment
dc.subject.otherCAR (chimeric antigen receptor) T cells
dc.subject.othercell based therapy
dc.titleCurrent Perspectives, Challenges and Advances in Cell Based Therapies
dc.typebook
oapen.identifier.doi10.3389/978-2-88963-564-1
oapen.relation.isPublishedBybf5ce210-e72e-4860-ba9b-c305640ff3ae
oapen.relation.isbn9782889635641
oapen.pages192


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