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dc.contributor.editorFromm, Michael
dc.contributor.editorKrug, Susanne M.
dc.date.accessioned2021-05-01T15:46:31Z
dc.date.available2021-05-01T15:46:31Z
dc.date.issued2020
dc.identifierONIX_20210501_9783039433001_1061
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/69315
dc.description.abstractFor a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.
dc.languageEnglish
dc.subject.classificationbic Book Industry Communication::M Medicine
dc.subject.othertissue barrier
dc.subject.othertight junction
dc.subject.otherclaudins
dc.subject.othertricellulin
dc.subject.othertight junctions
dc.subject.otherorgan preservation
dc.subject.otherintestine
dc.subject.othertransplantation
dc.subject.otherischemia
dc.subject.otherintestinal mucosa
dc.subject.otherlung
dc.subject.otherepithelia
dc.subject.otherinterleukin 13
dc.subject.otherUBE2Z
dc.subject.otherubiquitin
dc.subject.otherosmolality
dc.subject.otherhydrostatic pressure
dc.subject.othercancer
dc.subject.othersensor
dc.subject.othertricellular tight junctions
dc.subject.otherendometrial cancer
dc.subject.otherepithelial barrier dysfunction
dc.subject.otherClaudin-7
dc.subject.otherpermeability
dc.subject.otherWNK4
dc.subject.otherepithelial sodium channel (ENaC), collecting duct cells
dc.subject.otherclaudin-1
dc.subject.otherhydrogen peroxide
dc.subject.otherphosphorylation
dc.subject.otherclaudin
dc.subject.otherangulin
dc.subject.otherdrug development
dc.subject.otherangubindin-1
dc.subject.otherClostridium perfringens enterotoxin
dc.subject.otherClostridium perfringens iota-toxin
dc.subject.otherantibody
dc.subject.otherMz-ChA-1 cells
dc.subject.otherbiliary epithelial cells
dc.subject.otherphosphatidylcholine
dc.subject.othermucus
dc.subject.otherparacellular transport
dc.subject.otheratopic dermatitis
dc.subject.othercytokines
dc.subject.otherSTAT3
dc.subject.otherZO-2
dc.subject.othercholestasis
dc.subject.othergene transcription
dc.subject.otherhypertrophy
dc.subject.othertumor suppressor
dc.subject.otherNLS
dc.subject.otherNES
dc.subject.otherCaSR
dc.subject.otherRhoA
dc.subject.otherbarrier function
dc.subject.otherparacellular permeability
dc.subject.otherantidiuretic hormone
dc.subject.otherClaudin-14
dc.subject.otherCLDN14
dc.subject.otherhearing loss
dc.subject.othervestibular function
dc.subject.othercochlear implantation
dc.subject.otherHepatitis C Virus
dc.subject.otherviral entry
dc.subject.otherepidermal barrier
dc.subject.otherreconstructed human epidermis
dc.subject.otherclaudin targeting
dc.subject.otherCampylobacter jejuni
dc.subject.othercurcumin
dc.subject.otherapoptosis
dc.subject.otherco-culture
dc.subject.othermouse colon
dc.subject.otherTNF
dc.subject.otherNFκB
dc.subject.otherlipolysis-stimulated lipoprotein receptor (LSR)
dc.subject.otherepithelial barrier
dc.subject.othercell–cell contact
dc.subject.othercaspase
dc.subject.otherkidney stones
dc.subject.otherion reabsorption
dc.subject.otherquercetin
dc.subject.otherbrain barriers
dc.subject.otherblood-brain barrier
dc.subject.otherneurovascular unit
dc.subject.otherblood-cerebrospinal fluid barrier
dc.subject.otherarachnoid barrier
dc.subject.otherglia limitans
dc.subject.otheradherens junctions
dc.subject.otherparacellular sodium transport
dc.subject.otherthick ascending limb
dc.subject.othernephropathy
dc.subject.otherHELIX syndrome
dc.subject.otherhypokalemia
dc.subject.otherhypermagnesemia
dc.subject.otheranhidrosis
dc.subject.othergland dysfunction
dc.subject.otheraging
dc.subject.otherblood–brain barrier
dc.subject.othermutations
dc.subject.otherkidney
dc.subject.otherliver
dc.subject.otherskin
dc.subject.otherhuman
dc.subject.othermice
dc.subject.otherdisease
dc.subject.otherin silico
dc.subject.otherdrug discovery
dc.subject.othermembrane proteins
dc.subject.otherprotein interactions
dc.subject.othermolecular dynamics
dc.subject.otherantibiotic-associated hemorrhagic colitis
dc.subject.otherKlebsiella oxytoca
dc.subject.othertight junction assembly
dc.subject.othermonocytes
dc.subject.otherceliac disease
dc.subject.otherclaudin-2
dc.subject.otherepithelium
dc.subject.otherinflammation
dc.subject.otherfibrosis
dc.subject.otherproliferation
dc.subject.othermigration
dc.subject.othertricellular tight junction
dc.subject.otherparacellular water transport
dc.subject.othertight epithelium
dc.subject.otherMDCK C7 cells
dc.subject.othercell growth
dc.subject.otherendothelia
dc.subject.otheradherens junction
dc.subject.otherapical junctional complex
dc.subject.otherAMP-activated protein kinase (AMPK)
dc.subject.otherparacellular barrier
dc.subject.otherprotein structure
dc.subject.otherprotein domain
dc.subject.otheroccludin
dc.subject.otherjunctional adhesion molecule
dc.subject.otherzonula occludens
dc.subject.otherMAGUK proteins
dc.subject.otherPDZ domain
dc.subject.otherstem cell
dc.subject.otherchemoresistance
dc.subject.otherretinal pigment epithelium
dc.subject.otherretinopathy
dc.subject.otherbarrier formation
dc.subject.othercollecting duct
dc.subject.otherclaudin-5
dc.subject.otherneuropathic pain
dc.subject.othernerve injury
dc.subject.otherdorsal root ganglion
dc.subject.otherenteropathogenic E. coli (EPEC)
dc.subject.othertight junctions (TJ)
dc.subject.otherpolarity
dc.subject.otheratypical aPKCζ
dc.subject.othertransepithelial electrical resistance (TER)
dc.subject.othersorting nexin 9 (SNX9)
dc.subject.otherEspF
dc.subject.otherclaudin 1
dc.subject.othertumor
dc.subject.othermetastasis
dc.subject.otherepithelial to mesenchymal transition
dc.subject.othercerebral cavernous malformation
dc.subject.otherendothelial barrier
dc.subject.otherRho
dc.subject.otherROCK
dc.subject.otherMEKK3
dc.subject.otherion transport
dc.subject.otherion channel
dc.subject.othersuper-resolution microscopy
dc.subject.otherstructured illumination microscopy
dc.subject.otherstimulated emission depletion
dc.subject.othersingle molecule localization microscopy
dc.subject.otherClaudin
dc.subject.otherblood-biliary barrier
dc.subject.otherchronic liver disease
dc.subject.otherhepatocellular carcinoma
dc.subject.othercholangiocellular carcinoma
dc.subject.otherNISCH syndrome
dc.subject.otherrepair
dc.subject.otherNHE2
dc.subject.otherClC-2
dc.subject.otherinflammatory bowel disease
dc.subject.othermucosal immunology
dc.subject.otherZO-1
dc.subject.otheractomyosin
dc.subject.otheraquaporin
dc.subject.otherdrinking rate
dc.subject.otherepithelial fluid transport
dc.subject.otherenterocyte
dc.subject.otherosmoregulation
dc.subject.otherparacellular
dc.subject.otherproximal tubule
dc.subject.othercalcium permeability
dc.subject.otherclaudin-12
dc.subject.otherparacellular channels and barriers
dc.subject.othercell polarity
dc.subject.otherpathogens
dc.subject.otherimmune cells
dc.subject.otherenvironmental sensors
dc.titleThe Tight Junction and Its Proteins
dc.title.alternativeMore Than Just a Barrier
dc.typebook
oapen.identifier.doi10.3390/books978-3-03943-301-8
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn9783039433001
oapen.relation.isbn9783039433018
oapen.pages432
oapen.place.publicationBasel, Switzerland


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