Antitumoral Properties of Natural Products
Fabiani, Roberto (editor)
Cancer is one of the major causes of death worldwide. It is a multifactorial heterogeneous disease characterized by the transformation of normal cells into malignant cells, which acquire an uncontrolled growth, immortality, invasiveness, and ability to form distant metastasis. Natural bioactive molecules may interfere with these processes and inhibit the carcinogenesis process. In this book, new molecules and extracts, mainly derived from plants, have been described as being able to alter tumor cell behavior and target several abnormal molecular pathways in cancer cells. Among different cancer cells, the more studied include those derived from glioblastoma, osteosarcoma, lung, breast and gastric cancer. These natural products could be an attractive source for the development of new preventative and therapeutic agents against cancer. They may be more selective and have weaker adverse effects compared to conventional chemotherapy drugs that are actually used for cancer treatment. Clinical trials are necessary to demonstrate whether the in vitro and in vivo animal data are reproduced in humans before the application of natural products in cancer prevention and treatment.
Keywordscytotoxic activity; NCI-60 cancer cell line; pristimerin; Salacia crassifolia; Celastraceae; Brazilian Cerrado biome; Salacia elliptica; Cheiloclinium cognatum; Plenckia populnea; Aspergillus fumigatus; Cordyceps sinensis; isochromanes; chiral resolution; ECD calculation; cytotoxicity; coronarin D; JNK; osteosarcoma; Zeylenone; gastric cancer; invasion; migration; apoptosis; anti-cancer agents; anthraquinones; glycosyltransferase; Dendrobium officinale; structure elucidation; anti-tumor activity; plantation mode; AR; Ganoderma tsugae; lipogenesis; prostate cancer; SREBP-1; ursolic acid; betulinic acid; triterpenoids; necrotic; quercetin; quercetagetin; patuletin; lichen; secondary metabolites; tumidulin; stemness potential; colorectal cancer cells; oncogene; transcriptional regulation; neferine; FAK/S6K1; autophagy; human neuroblastoma cells; natural yellow Monascus pigments; water-soluble; antioxidation; MCF-7 cells; phloretin; cell proliferation; inflammation; glucose uptake; Catalpa speciosa; Taxus cuspidata; Magnolia acuminata; phenols; antioxidants; anticancer; Colocasia esculenta; food bioactive; tarin; stable nanocapsules; entrapment efficiency; no-toxicity; preclinical tests; antitumoral activity; chemotherapeutic adjuvant; grape leaves; ASE; TP; Antioxidant activities; Antiproliferative; pro-apoptotic effects; Gene expression; Nutraceuticals; Cucurbitacin B; gefitinib-resistant NSCLC; EGFR; lysosomal degradation; CIP2A; zerumbone; cancer; NF-κB; IL-6/JAK2/STAT3; Akt; FOXO1; multiple myeloma; quality control; naringenin; flavonoids; traditional preparation; cancer stem cells; phytochemicals; plant-derived foods; fruit; vegetable; cell signaling; Artemisia absinthium; endoplasmic reticulum stress; mitochondrial-dependent pathway; melanoma; bee venom; melittin; temozolomide; AKT; MAPK; antrodin C; mTOR; metabolic stability; capsazepine; inflammatory diseases; ROS; TRPV1; PI3K/AKT/mTOR; CLE-10; LC3; MDA-MB-231; lactoferrin hydrolysate; copper; manganese; gastric cancer cells; anti-cancer activity; molecular mechanism; natural product alkaloids; cephalotaxine; protein synthesis inhibition; antiproliferation agents; folk medicine; DLD-1 cells; doxorubicin; chemotherapy; drug resistance; CrataBL; glioblastoma; mesenchymal stem cells; microenvironment; plant lectin; protease inhibitor; cryptolepine; neocryptolepine; isocryptolepine; antiproliferative activity; structure activity relationships; Licochalcone A; ATM-Chk2; 13-ethylberberine; mitochondrial ROS; RT-R breast cancer cells; diallyl disulfide; PI3K/Akt/mTOR pathway; Pulsatilla saponin D; SB365; glioblastoma multiforme; autophagic flux inhibition; lysosomal membrane permeabilization; mitochondrial membrane potential; CLEFMA; p38; proanthocyanins; TNF-α; lung adenocarcinoma; natural compounds; cervical cancer; cell cycle arrest; dicentrine; metastasis; glioma; semi-synthetic derivative; ingenol; Euphorbia tirucalli; protein kinase C; seaweed; porphyran; carrageenan; anti-cancer; natural products; n/a
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Publication date and placeBasel, Switzerland, 2020
Research & information: general
Biology, life sciences