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dc.contributor.editorNakagawa-Goto, Kyoko
dc.date.accessioned2021-05-01T15:40:50Z
dc.date.available2021-05-01T15:40:50Z
dc.date.issued2020
dc.identifierONIX_20210501_9783039430086_833
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/69087
dc.description.abstractCancer is the second leading cause of death worldwide, and was accountable for an estimated 9.6 million deaths in 2018. Nowadays, about 1 in 6 deaths in the world is due to cancer. Another major global public health issue is HIV. Over 70 million people have been infected with the HIV virus and about 35 million people have died of HIV-related illness, since the start of the epidemic. We have been fighting against these two serious diseases by finding successful treatments. The discovery of effective drugs is important for fighting cancer and HIV. Natural products, which are secondary metabolites produced by various living organisms, have been playing a principal role in drug discovery and developments, because of their structural and biological diversity. Many clinically used drugs have come from natural products; for example, more than 60% of anticancer drugs currently in clinical use are derived from natural sources. This Special Issue aims to collect original research and review articles focusing on notable and recent contributions to the discovery and development of novel anticancer and anti-HIV drug candidates from natural sources. Up-to-date knowledge from various research fields is welcome. This could be of great interest for scientists working in different research areas, such as natural product chemistry, including isolation and structural elucidation; phytochemistry; medicinal chemistry, including chemically modified natural compounds with improved biological activity; pharmacology; molecular biology; mechanisms of action study using natural products or related compounds; pharmacognosy, etc. Biological studies of natural extracts without an appropriate chemical characterization may not be considered.
dc.languageEnglish
dc.subject.classificationthema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: generalen_US
dc.subject.othernatural phaeosphaeride A
dc.subject.otherantitumor activity
dc.subject.otherhuman tumor cell lines
dc.subject.otherHEF cell line
dc.subject.otheracute toxicity
dc.subject.otheraspidosperma-type
dc.subject.othermonoterpenoid indole alkaloids
dc.subject.otherantiproliferative activity
dc.subject.othertubulin inhibitor
dc.subject.otherBousigonia mekongensis
dc.subject.otherursolic acid
dc.subject.otherDOTA
dc.subject.othertriterpenoids
dc.subject.othercytotoxicity
dc.subject.otherditerpenoid alkaloids
dc.subject.otherhuman tumor cells
dc.subject.otherlipojesaconitine
dc.subject.otherdelcosine
dc.subject.otherdelpheline
dc.subject.otherkobusine
dc.subject.otherpseudokobusine
dc.subject.otherBRAF inhibitor
dc.subject.otherMentha aquatica var. Kenting Water Mint
dc.subject.otheressential oil
dc.subject.otherchemoprevention
dc.subject.othertwo-stage skin carcinogenesis
dc.subject.othermelanoma
dc.subject.othercurcumin analog
dc.subject.otherapoptosis
dc.subject.otheroxidative stress
dc.subject.otherdrug–drug interaction
dc.subject.othertamoxifen
dc.subject.othertaxol
dc.subject.othercisplatin
dc.subject.otherArtemisia absinthium L.
dc.subject.otherantioxidants
dc.subject.othertotal phenolic content
dc.subject.othermelanoma and breast cancer cell line
dc.subject.otherHaCaT cells
dc.subject.otherinflammation
dc.subject.otherbreast cancer
dc.subject.othercell cycle
dc.subject.otherflavonoids
dc.subject.otherreactive oxygen species
dc.subject.othertumor suppression
dc.subject.otherantiretroviral agents
dc.subject.otheranti-HIV
dc.subject.othermarine metabolites
dc.subject.othernatural products
dc.subject.otherdrug development
dc.subject.otherIvalin
dc.subject.otherCarpesium divaricatum
dc.subject.otherhepatocellular carcinoma
dc.subject.othermitochondria-mediated apoptosis
dc.subject.otherNF-κB
dc.subject.otherHernandia nymphaeifolia
dc.subject.otherbutanolides
dc.subject.otherlignan glycosides
dc.subject.othercoumarins
dc.subject.otherantiangiogenic
dc.subject.othercancer
dc.subject.othernatural agents
dc.subject.otherchemistry
dc.subject.othermedicine
dc.subject.othercancer stem cell
dc.subject.othercervical cancer
dc.subject.otherpterostilbene
dc.subject.otherresveratrol
dc.subject.othercaffeic acid
dc.subject.othercancer multidrug resistance
dc.subject.otherP-glycoprotein
dc.subject.otherphenolic acid
dc.subject.otheroxypeucedanin
dc.subject.otherAngelica dahurica
dc.subject.otherantiproliferation
dc.subject.otherG2/M phase cell cycle arrest
dc.subject.otherp53
dc.subject.otherSK-Hep-1
dc.subject.otherhepatoma cells
dc.subject.otherallyl isothiocyanate
dc.subject.otherbenzyl isothiocyanate
dc.subject.othersulforaphane
dc.subject.otherphenethyl isothiocyanate
dc.subject.otherbladder cancer
dc.subject.otherquercetin
dc.subject.otheroral squamous cell carcinoma cells
dc.subject.othermetastasis
dc.subject.othercell cycle arrest
dc.subject.otherepithelial-to-mesenchymal transition
dc.subject.othermatrix metalloproteinase
dc.subject.othertransforming growth factor-β1
dc.subject.otherβ-lapachone
dc.titleAntitumor and Anti-HIV Agents from Natural Products
dc.typebook
oapen.identifier.doi10.3390/books978-3-03943-009-3
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn9783039430086
oapen.relation.isbn9783039430093
oapen.pages338
oapen.place.publicationBasel, Switzerland


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