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dc.contributor.editorČipak Gašparović, Ana
dc.date.accessioned2021-05-01T15:16:33Z
dc.date.available2021-05-01T15:16:33Z
dc.date.issued2020
dc.identifierONIX_20210501_9783039360888_390
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/68644
dc.description.abstractCancer is a great challenge to efficient therapy due to biological diversity. Disturbed oxidative homeostasis in cancer cells certainly contributes to differential therapy response. Further, one of the hallmarks of cancer cells is adaptation which includes fine tuning of the cellular metabolic and signalling pathways as well as transcription profiles. There are several factors which contribute to the tumor diversity and therapy response, and oxidative stress is certainly one of them. Changes in oxygen levels due to hypoxia/reoxygenation during tumor growth modulate antioxidative patterns finally supporting increased cell diversity and adaptation to stressing conditions. Additionally, cancer chemotherapy based on ROS production can also induce also adaptation. To counteract these negative effects natural products are often used for their antioxidant activities as well as photodynamic therapy supported by novel chemosensitizers. Understanding of possible pathways which can trigger antioxidant defence at a certain time during cancer development can also provide possible strategies in fighting cancer.
dc.languageEnglish
dc.subject.classificationthema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issuesen_US
dc.subject.otherNQO1
dc.subject.otherNQO1*2
dc.subject.otherpolymorphism
dc.subject.otherquinone
dc.subject.otherbreast cancer
dc.subject.othermenadione
dc.subject.otherlapachone
dc.subject.otherdoxorubicin
dc.subject.otherascorbate
dc.subject.otheroxidative stress
dc.subject.otherreactive oxygen species
dc.subject.othersperm
dc.subject.othercancer chemotherapy
dc.subject.otherantioxidant therapy
dc.subject.otherantioxidant proteins
dc.subject.otherchemoresistance
dc.subject.otheroxaliplatin
dc.subject.other5-Fluorouracil
dc.subject.othermyelodysplastic syndromes
dc.subject.othercarbonylation
dc.subject.otherdeferasirox
dc.subject.otherovary
dc.subject.othercalcium channel
dc.subject.otherTrolox
dc.subject.othergranulosa cell tumor
dc.subject.othercell death
dc.subject.othermitochondria
dc.subject.otherphotodynamic therapy
dc.subject.othersinglet oxygen
dc.subject.othernitric oxide
dc.subject.otherlight
dc.subject.othercombination therapy
dc.subject.otherantioxidants
dc.subject.otherbleomycin
dc.subject.othercancer treatment
dc.subject.otherchemotherapy-induced toxicity
dc.subject.othercisplatin
dc.subject.otherfree radicals
dc.subject.othermethotrexate
dc.subject.otherozone therapy
dc.subject.otherlung cancer
dc.subject.othercancer metabolism
dc.subject.otherreactive oxygen species (ROS)
dc.subject.othertherapy resistance
dc.subject.othernew therapeutic strategies
dc.subject.otherbreast cancer stem cells
dc.subject.other4-hydroxy-2-nonenal
dc.subject.otherextracellular matrix
dc.subject.otherNRF2
dc.subject.otherbardoxolone methyl
dc.subject.otherprostate cancer
dc.subject.othercastration-resistant prostate cancer
dc.subject.otherandrogen receptor (AR), AR-V7
dc.subject.otheranti-androgen
dc.subject.otherenzalutamide
dc.subject.otherandrogen deprivation therapy
dc.subject.othercancer
dc.subject.otherantioxidant
dc.subject.othertriphala
dc.subject.otherayurveda
dc.subject.otherchemoprevention and chemotherapy
dc.subject.othern/a
dc.titleFree Radical Research in Cancer
dc.typebook
oapen.identifier.doi10.3390/books978-3-03936-089-5
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn9783039360888
oapen.relation.isbn9783039360895
oapen.pages192
oapen.place.publicationBasel, Switzerland


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