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dc.contributor.editorRupasinghe, H.P. Vasantha
dc.date.accessioned2021-05-01T15:11:53Z
dc.date.available2021-05-01T15:11:53Z
dc.date.issued2021
dc.identifierONIX_20210501_9783036500003_267
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/68521
dc.description.abstractFlavonoids are ubiquitously present in plant-based foods and natural health products. The molecule of flavonoids is characterized by a 15-carbon skeleton of C6–C3–C6, with the different structural configuration of subclasses. The major subclasses of flavonoids with health-promotional properties are the flavanols or catechins (e.g., epigallocatechin 3-gallate from green tea), the flavones (e.g., apigenin from celery), the flavonols (e.g., quercetin glycosides from apples, berries, and onion), the flavanones (e.g., naringenin from citrus), the anthocyanins (e.g., cyanidin-3-O-glucoside from berries), and the isoflavones (e.g., genistein from soya beans). Scientific evidence has strongly shown that regular intake of dietary flavonoids in efficacious amounts reduces the risk of oxidative stress- and chronic inflammation-mediated pathogenesis of human diseases such as cardiovascular disease, certain cancers, and neurological disorders. The physiological benefits of dietary flavonoids have been demonstrated to be due to multiple mechanisms of action, including regulating redox homeostasis, epigenetic regulations, activation of survival genes and signaling pathways, regulation of mitochondrial function and bioenergetics, and modulation of inflammation response. The role of flavonoids on gut microbiota and the impact of microbial metabolites of flavonoids on optimal health has begun to unravel. The complex physiological modulations of flavonoid molecules are due to their structural diversity. However, some flavonoids are not absorbed well, and their bioavailability could be enhanced through structural modifications and applications of nanotechnology, such as encapsulation. This Special Issue consists of four review articles on flavonoids and 15 original research articles, which cover the latest findings on the role of dietary flavonoids and their derivatives in disease prevention and treatment.
dc.languageEnglish
dc.subject.classificationbic Book Industry Communication::H Humanities
dc.subject.classificationbic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFP Social interaction
dc.subject.otherluteolin
dc.subject.otherapigenin
dc.subject.otherbacoside A
dc.subject.otherbacopaside I
dc.subject.othervasorelaxation
dc.subject.otherisorhamnetin
dc.subject.otherflavonoid
dc.subject.otherbacterial sepsis
dc.subject.othertoll-like receptor 4
dc.subject.otherinflammation
dc.subject.othercitrus flavonoids
dc.subject.otherneohesperidin
dc.subject.otheranti-aging activity
dc.subject.otherchronological lifespan
dc.subject.othersynergistic effect
dc.subject.otherclinical trials
dc.subject.othernatural products
dc.subject.otherhyperalgesia
dc.subject.otherallodynia
dc.subject.otheranalgesia
dc.subject.otherhypersensitivity
dc.subject.othercytokines
dc.subject.otherNF-kB
dc.subject.otherdefatted pitaya seed
dc.subject.otherextraction
dc.subject.otherphenolic content
dc.subject.otherflavonoid content
dc.subject.otherantioxidant activity
dc.subject.otherresponse surface methodology
dc.subject.otherflavonoids
dc.subject.otheraglycons
dc.subject.otherglycosides
dc.subject.otherIL-1β
dc.subject.otherTNF-α
dc.subject.otherIL-6
dc.subject.otherIL-8
dc.subject.otherpro-inflammatory cytokines
dc.subject.otherAcer okamotoanum
dc.subject.otherafzelin
dc.subject.otherisoquercitrin
dc.subject.otherobesity
dc.subject.otherquercitrin
dc.subject.otheraspirin
dc.subject.othercancer prevention
dc.subject.otherhydroxybenzoic acids
dc.subject.othercell cycle
dc.subject.otherCDKs
dc.subject.othercolorectal cancer
dc.subject.otherinfectious diseases
dc.subject.otheramoebiasis
dc.subject.otherMexican oregano
dc.subject.otherbioguided isolation
dc.subject.otherantiprotozoal agents
dc.subject.otherflavones
dc.subject.othercancer
dc.subject.othermicrobiome
dc.subject.othermolecular mechanisms
dc.subject.othergene and protein regulatory networks
dc.subject.othermacrophages
dc.subject.otherNF-κB
dc.subject.otherIKKβ, inflammatory cytokines
dc.subject.otherapoptosis
dc.subject.otherfoods for health
dc.subject.othertangeretin
dc.subject.othercancer stem cells
dc.subject.otherStat3
dc.subject.othercitrus
dc.subject.otherCD44+/CD24−
dc.subject.otherphytochemicals
dc.subject.otherflavonoids and their derivatives
dc.subject.otherphytomedicine
dc.subject.otherCOVID-19
dc.subject.otherSARS-COV-2
dc.subject.othersmart nanoparticles
dc.subject.othernon-flavonoids
dc.subject.othermembrane PUFAs profile
dc.subject.othercell morphology
dc.subject.otherhuman colon cancer cells
dc.subject.othercranberry
dc.subject.otherurinary tract infections
dc.subject.otherUTIs
dc.subject.otheruropathogenic Escherichia coli
dc.subject.otherUPEC
dc.subject.otherflavan-3-ols
dc.subject.otherA-type proanthocyanidins
dc.subject.otherphenolic metabolites
dc.subject.otherantiadhesive activity
dc.subject.otherprobiotics
dc.subject.otheranthocyanin
dc.subject.othertobacco-specific nitrosamine
dc.subject.othercarcinogenesis
dc.subject.othercell proliferation
dc.subject.othercancer chemoprevention
dc.subject.otherlung cancer
dc.subject.otherchalcones
dc.subject.otherDNA damage
dc.subject.otheranticancer activity
dc.subject.othercanine cancer cell lines
dc.subject.otherangiogenesis
dc.subject.otherin-vivo angiogenesis
dc.subject.otherCAM assay
dc.subject.otherSAR
dc.subject.othern/a
dc.subject.othercognition
dc.subject.otherpassive avoidance test
dc.subject.othermemory extinction
dc.subject.othermice
dc.subject.othermicroglia
dc.subject.otherneuroprotection
dc.subject.otherblack rice cyanidin-3-O-glucoside
dc.subject.otherwood sterols
dc.subject.otherdyslipidemia
dc.subject.otherCVD
dc.titleFlavonoids and Their Disease Prevention and Treatment Potential
dc.typebook
oapen.identifier.doi10.3390/books978-3-0365-0001-0
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn9783036500003
oapen.relation.isbn9783036500010
oapen.pages346
oapen.place.publicationBasel, Switzerland


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