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dc.contributor.editorNopoulos, Peggy C.
dc.date.accessioned2021-05-01T15:06:24Z
dc.date.available2021-05-01T15:06:24Z
dc.date.issued2021
dc.identifierONIX_20210501_9783039438112_40
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/68296
dc.description.abstractThe Special Issue “Juvenile Onset Huntington’s Disease” highlights the growing interest in understanding the unique aspects of this ultra-rare disorder. After decades of research, gene therapy trials are underway for Adult Onset Huntington’s Disease (AOHD). However, patients with Juvenile Onset Huntington’s Disease (JOHD) are often excluded from these efforts, leaving many questions regarding its phenomenology. The current issue includes seven articles spanning work on the difficult emotional experiences of parents of children with JOHD; a review of the clinical manifestations of JOHD; behavioral issues in JOHD; CAG repeat and age of motor onset; autonomic nervous system dysfunction; and abnormality in MRI metabolic markers. Finally, a review of the therapeutic advances is included, highlighting future possibilities of clinical trials in JOHD subjects. The HD community—patients, family members at-risk for HD, caregivers, health-care professionals and scientists—is keen on expanding our understanding of JOHD. In the flurry of research on AOHD, those with JOHD were seemingly ‘left behind.’ The study of patients who are afflicted early in life with HD has become imperative, with this Special Issue representing just the beginning of the required effort to address this urgent need.
dc.languageEnglish
dc.subject.classificationthema EDItEUR::M Medicine and Nursingen_US
dc.subject.otherHuntington’s disease
dc.subject.otherCAG repeat
dc.subject.othermutant huntingtin (mHTT)
dc.subject.othertherapeutics
dc.subject.otherneurodegeneration
dc.subject.otherjuvenile Huntington’s disease
dc.subject.otherpediatric Huntington’s disease
dc.subject.otherearly-onset Huntington’s disease
dc.subject.otherpersonal experiences
dc.subject.othercaregivers
dc.subject.othercase series
dc.subject.otherjuvenile-onset Huntington’s disease
dc.subject.otherT1-Rho
dc.subject.otherneuroimaging
dc.subject.otherbehavioral regulation
dc.subject.otherexecutive function
dc.subject.othertrinucleotide repeat disorder
dc.subject.otherCAG
dc.subject.othermotor onset
dc.subject.otherjuvenile-onset Huntington’s Disease
dc.subject.otherautonomic
dc.subject.othern/a
dc.titleJuvenile Onset Huntington's Disease
dc.typebook
oapen.identifier.doi10.3390/books978-3-03943-812-9
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0
oapen.relation.isbn9783039438112
oapen.relation.isbn9783039438129
oapen.pages102
oapen.place.publicationBasel, Switzerland


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