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dc.contributor.editorCheng, Yue
dc.date.accessioned2021-04-20T15:19:02Z
dc.date.available2021-04-20T15:19:02Z
dc.date.issued2012
dc.identifierONIX_20210420_9789533078793_867
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/65510
dc.description.abstractFunctional evidence obtained from somatic cell fusion studies indicated that a group of genes from normal cells might replace or correct a defective function of cancer cells. Tumorigenesis that could be initiated by two mutations was established by the analysis of hereditary retinoblastoma, which led to the eventual cloning of RB1 gene. The two-hit hypothesis helped isolate many tumor suppressor genes (TSG) since then. More recently, the roles of haploinsufficiency, epigenetic control, and gene dosage effects in some TSGs, such as P53, P16 and PTEN, have been studied extensively. It is now widely recognized that deregulation of growth control is one of the major hallmarks of cancer biological capabilities, and TSGs play critical roles in many cellular activities through signaling transduction networks. This book is an excellent review of current understanding of TSGs, and indicates that the accumulated TSG knowledge has opened a new frontier for cancer therapies.
dc.languageEnglish
dc.subject.classificationthema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncologyen_US
dc.subject.otherOncology
dc.titleTumor Suppressor Genes
dc.typebook
oapen.identifier.doi10.5772/1337
oapen.relation.isPublishedBy78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6
oapen.relation.isbn9789533078793
oapen.relation.isbn9789535167440
oapen.imprintIntechOpen
oapen.pages346


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