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dc.contributor.authorAnne L. Astier*
dc.contributor.authorDavid A. Hafler*
dc.date.accessioned2021-02-12T05:10:45Z
dc.date.available2021-02-12T05:10:45Z
dc.date.issued2015*
dc.date.submitted2016-04-07 11:22:02*
dc.identifier18854*
dc.identifier.issn16648714*
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/60449
dc.description.abstractNaïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, changing both phenotype and function. Differentiation into a specific subset depends on the nature of the antigen and of the environmental milieu. Notably, certain nutrients, such as vitamins A and D, sodium chloride, have been shown to modulate T cell responses and influence T cell differentiation. Parasite infection can also skew Th differentiation. Similarly, the gut microbiota regulates the development of immune responses. Lastly, the key role of metabolism on T cells has also been demonstrated. This series of articles highlights some of the multiple links existing between environmental factors and T cell responses.*
dc.languageEnglish*
dc.relation.ispartofseriesFrontiers Research Topics*
dc.subjectR5-920*
dc.subjectRC581-607*
dc.subject.otherregulatory T cells*
dc.subject.otherVitamin D*
dc.subject.otherhelminth*
dc.subject.otherT cells*
dc.subject.otherMetabolism*
dc.subject.othermicrobiome*
dc.titleT Cell Regulation by the Environment*
dc.typebook
oapen.identifier.doi10.3389/978-2-88919-733-0*
oapen.relation.isPublishedBybf5ce210-e72e-4860-ba9b-c305640ff3ae*
oapen.relation.isbn9782889197330*
oapen.pages115*


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