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dc.contributor.authorShiina, Takashi*
dc.contributor.authorDijkstra, Johannes M.*
dc.contributor.authorKulski, Jerzy K.*
dc.date.accessioned2021-02-11T18:34:35Z
dc.date.available2021-02-11T18:34:35Z
dc.date.issued2020*
dc.date.submitted2020-04-07 23:07:08*
dc.identifier44737*
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/52604
dc.description.abstractThe major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.*
dc.languageEnglish*
dc.subjectQH301-705.5*
dc.subjectQ1-390*
dc.subject.otherHCP5*
dc.subject.othern/a*
dc.subject.othercamels*
dc.subject.otherMHC*
dc.subject.otherSTK19*
dc.subject.othermajor histocompatibility complex*
dc.subject.otherhuman papillomavirus (HPV)*
dc.subject.otherT-cell receptor*
dc.subject.otherT1DGC*
dc.subject.otherbottleneck*
dc.subject.othermicro-mini-pigs*
dc.subject.otherlife history*
dc.subject.othercomputational analysis*
dc.subject.otherhepatocellular carcinoma*
dc.subject.otherphase*
dc.subject.otherBactrian camel*
dc.subject.otherNSDK*
dc.subject.othermelanoma*
dc.subject.otherantigen*
dc.subject.otherautoimmune disease*
dc.subject.otherRD*
dc.subject.otherselection*
dc.subject.otherdisease resistance*
dc.subject.otherautoimmunity*
dc.subject.otherancestral haplotype*
dc.subject.otherSki complex*
dc.subject.otherDXO*
dc.subject.otherhigh-throughput sequencing*
dc.subject.otherconservation genetics*
dc.subject.otherSVA*
dc.subject.otherlncRNA*
dc.subject.otherankylosing spondylitis*
dc.subject.otherMHC genes*
dc.subject.otherviral peptides*
dc.subject.othercompeting endogenous RNA (ceRNA)*
dc.subject.otherastrogliosis*
dc.subject.otherbirds*
dc.subject.otherlong-fragment super haplotype*
dc.subject.otherSNP*
dc.subject.otherRLR*
dc.subject.otherHLA polymorphism*
dc.subject.other5??3? RNA decay*
dc.subject.otherexpression*
dc.subject.other3??5? mRNA turnover*
dc.subject.otherorthology*
dc.subject.otherlong-read sequencing*
dc.subject.otherdisease association*
dc.subject.otherdromedary*
dc.subject.otherpolyomavirus*
dc.subject.otherMHC-II-associated sperm-egg recognition*
dc.subject.otherexperimental medicine*
dc.subject.othersingle nucleotide polymorphism (SNP)*
dc.subject.otherfish*
dc.subject.otherSKIV2L*
dc.subject.otherproduction trait*
dc.subject.othermolecular dynamics simulation*
dc.subject.otherMacaca fascicularis*
dc.subject.otherhuman endogenous retrovirus (HERV)*
dc.subject.otherconcerted evolution*
dc.subject.otherpolymorphism*
dc.subject.otherOld World camels*
dc.subject.otherMHC polymorphism*
dc.subject.otherprotocol*
dc.subject.othernonclassical*
dc.subject.othergene duplication*
dc.subject.othermicroglial reaction*
dc.subject.otherhuman leukocyte antigen-E*
dc.subject.otherSKI2W*
dc.subject.otherquantitative trait loci (QTL) studies*
dc.subject.otherantiviral immunity*
dc.subject.otherhuman immunodeficiency virus (HIV)*
dc.subject.otherfounder effect*
dc.subject.othergiant panda*
dc.subject.otherdomain movements*
dc.subject.otherBK virus*
dc.subject.otherpromoter-proximal transcriptional pause*
dc.subject.othertype 1 diabetes (T1D)*
dc.subject.otherRP1*
dc.subject.othermiR1236*
dc.subject.otherKIR*
dc.subject.othersynaptic covering*
dc.subject.otherswine leukocyte antigen*
dc.subject.othercynomolgus macaque*
dc.subject.otherHLA*
dc.subject.otherkidney transplantation*
dc.subject.other?2m knockout mice*
dc.subject.otherDOM3Z*
dc.subject.otherinterferon ?*
dc.subject.otherethnic populations in China*
dc.subject.otherecology*
dc.subject.otherKIR–HLA pairs*
dc.subject.otherexosomes*
dc.subject.othermajor histocompatibility complex (MHC)*
dc.subject.otherMHC-I-based mother-fetus recognition*
dc.subject.otherRNA quality control*
dc.subject.otherautoimmune diseases*
dc.subject.otherNELF-E*
dc.subject.otherhaplotype*
dc.subject.othergenetic drift*
dc.subject.otherevolution*
dc.subject.othernonhuman primate models*
dc.subject.otherHLA-B27*
dc.subject.otherPNS/CNS interface*
dc.subject.otherrisk genes*
dc.subject.otherpedigree*
dc.subject.otherMHC-I- and MHC-II-dependent inter-individual recognition*
dc.subject.otherregulation*
dc.subject.othercrested ibis*
dc.subject.otherreproductive performance*
dc.subject.othernephropathy*
dc.subject.othercancer*
dc.subject.othernuclear kinase*
dc.subject.othertrichohepatoenteric syndrome*
dc.titleMajor Histocompatibility Complex (MHC) in Health and Disease*
dc.typebook
oapen.identifier.doi10.3390/books978-3-03928-073-5*
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0*
virtual.oapen_relation_isPublishedBy.publisher_nameMDPI - Multidisciplinary Digital Publishing Institute
virtual.oapen_relation_isPublishedBy.publisher_websitewww.mdpi.com/books
oapen.relation.isbn9783039280728*
oapen.relation.isbn9783039280735*
oapen.pages375*
oapen.edition1st*


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