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Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges

dc.contributor.authorGabazza, Esteban C.*
dc.date.accessioned2021-02-11T17:48:58Z
dc.date.available2021-02-11T17:48:58Z
dc.date.issued2019*
dc.date.submitted2019-12-09 11:49:16*
dc.identifier42638*
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/51774
dc.description.abstractTissue fibrosis may occur for unknown causes or be the consequence of many pathological conditions including chronic inflammatory or infectious diseases, autoimmune disorders, graft rejection, or malignancy. On the other hand, malignant tumors have been identified in fibrotic tissues decades ago, and now accumulating evidence suggests that fibrotic lesions enhance the risk of cancer in several organs such as liver, lungs, and breast. Disruption of an organ parenchymal cells and of its normal structural scaffold during tissue fibrogenesis appears to induce loss of cell polarity, promoting uncontrolled cell proliferation that may eventually lead to cancer development. Many cellular and molecular abnormalities including aberrant expression of microRNAs, genetic and epigenetic alterations, evasion or delayed apoptosis, unregulated intracellular signal pathways, and dysregulation or defective intercellular communications have been proposed to explain this link between fibrogenesis and carcinogenesis. However, the precise mechanisms of this fibrosis-to-cancer transition remain unclear. This book presents a collection of reviews and original articles summarizing recent advances in understanding the molecular mechanisms of cancer development in fibrotic organs.*
dc.languageEnglish*
dc.subjectR5-920*
dc.subjectRC31-1245*
dc.subject.classificationthema EDItEUR::M Medicine and Nursingen_US
dc.subject.otherbleomycin*
dc.subject.othern/a*
dc.subject.otherregeneration*
dc.subject.otherantitumor efficacy*
dc.subject.otherlung cancer*
dc.subject.otherSOX2*
dc.subject.otherleiomyosarcoma*
dc.subject.otherlung cancer (LC)*
dc.subject.othernanoparticles*
dc.subject.othercytokines*
dc.subject.otherhepatocellular carcinoma*
dc.subject.othermetabolic reprogramming*
dc.subject.otherhepatic stellate cells*
dc.subject.otherangiogenesis*
dc.subject.othertransforming growth factor-?*
dc.subject.otheranaplastic lymphoma kinase*
dc.subject.otheridiopathic pulmonary fibrosis*
dc.subject.othergrowth factor*
dc.subject.otherpathogenesis*
dc.subject.othercancer-associated fibroblasts*
dc.subject.otherfibrosis*
dc.subject.otherlipopolysaccharide*
dc.subject.otherDHA*
dc.subject.otherlncRNA*
dc.subject.otherSREBP-1*
dc.subject.otherYAP*
dc.subject.otherprotein S*
dc.subject.othernon-small cell lung cancer (NSCLC)*
dc.subject.otheromega-3 fatty acid*
dc.subject.otherinflammation*
dc.subject.othermetastasis*
dc.subject.otherclinical symptoms*
dc.subject.othermiRNA*
dc.subject.othersmooth muscle tumor of uncertain malignant potential*
dc.subject.otherWnt*
dc.subject.otherinterstitial fluid pressure*
dc.subject.otherheterogeneity*
dc.subject.otherhepatocytes*
dc.subject.othermyometrium*
dc.subject.othertumor necrosis factor ?*
dc.subject.othertumor*
dc.subject.othertumor microenvironment*
dc.subject.otherextracellular matrix*
dc.subject.otherTAZ*
dc.subject.othercarcinogenesis*
dc.subject.othercystic formation*
dc.subject.otherpulmonary fibrosis*
dc.subject.otherHBV*
dc.subject.othercytokine*
dc.subject.othergenetic instability*
dc.subject.otherdiagnosis*
dc.subject.otherEMT*
dc.subject.othercrizotinib*
dc.subject.otherHippo pathway*
dc.subject.otherGPR120*
dc.subject.othermarker*
dc.subject.otherHCV*
dc.subject.othernon-alcoholic steatohepatitis*
dc.subject.otherpathology*
dc.subject.othercommon pathways*
dc.subject.otherapoptosis*
dc.subject.othertype I collagen*
dc.subject.otherGPR40*
dc.subject.otheracute lung injury*
dc.subject.otheruterine fibroid*
dc.subject.otherrenal injury*
dc.subject.otherpathophysiology*
dc.subject.otherreactive oxygen species*
dc.subject.otherimmunohistochemistry*
dc.subject.otherSMAD*
dc.subject.otherbutylidenephthalide*
dc.subject.otherleiomyoma*
dc.subject.othercirrhosis*
dc.subject.otherErk1/2*
dc.subject.othertargeted therapy*
dc.subject.otherTGF-?*
dc.subject.othermechanotransduction*
dc.subject.othertherapy*
dc.subject.otherbreast cancer*
dc.subject.otherhepatocellular carcinoma (HCC)*
dc.subject.otherhepatic stellate cells (HSCs)*
dc.subject.otheridiopathic pulmonary fibrosis (IPF)*
dc.subject.othercancer-associated fibroblasts (CAFs)*
dc.subject.othercancer*
dc.subject.othersignal pathway*
dc.subject.othertumor stiffness*
dc.titleLinks between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges*
dc.typebook
oapen.identifier.doi10.3390/books978-3-03921-707-6*
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0*
oapen.relation.isbn9783039217076*
oapen.relation.isbn9783039217069*
oapen.pages348*
oapen.edition1st*


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