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dc.contributor.authorGozzelino, Raffaella*
dc.contributor.authorPoli, Maura*
dc.contributor.authorArosio, Paolo*
dc.date.accessioned2021-02-11T16:41:58Z
dc.date.available2021-02-11T16:41:58Z
dc.date.issued2020*
dc.date.submitted2020-04-07 23:07:08*
dc.identifier44743*
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/50680
dc.description.abstractIron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.*
dc.languageEnglish*
dc.subjectQH301-705.5*
dc.subjectQD415-436*
dc.subjectQ1-390*
dc.subject.otherdevelopmental*
dc.subject.otherAnemia of chronic disease*
dc.subject.otherneurodegeneration*
dc.subject.othersupplementation*
dc.subject.otherMHC*
dc.subject.otheriron chelation therapy*
dc.subject.otherosteoblast*
dc.subject.otherserum biomarker*
dc.subject.otherFeSO4*
dc.subject.otherhaptoglobin*
dc.subject.otherprevention*
dc.subject.otherbrain development*
dc.subject.otherpituitary*
dc.subject.othertrauma*
dc.subject.otherhepcidin*
dc.subject.otherAlzheimer’s disease*
dc.subject.otherchaotropes*
dc.subject.othersocial behavior*
dc.subject.otherAfrica*
dc.subject.othermacrophage*
dc.subject.otheranemia of inflammation*
dc.subject.otherTfr2*
dc.subject.otherchelation*
dc.subject.othercardiomyocyte*
dc.subject.otherIV iron therapy*
dc.subject.otherOxidative stress*
dc.subject.othertreatment*
dc.subject.otherchronic kidney disease*
dc.subject.otheriron homeostasis*
dc.subject.otheroxygen sensing*
dc.subject.otheriron chelators*
dc.subject.otherage-related macular degeneration (AMD)*
dc.subject.otherpharmaceutical targets*
dc.subject.othernon-transferrin-bound iron (NTBI)*
dc.subject.otheriron dextran*
dc.subject.otherpulmonary arterial hypertension*
dc.subject.otherlabile iron*
dc.subject.otherlow and middle income countries*
dc.subject.otherferroportin*
dc.subject.othergut microbiota*
dc.subject.otherreducibility*
dc.subject.othernon-HFE*
dc.subject.otheroxidative stress*
dc.subject.otherantitumor compound*
dc.subject.othersenescence*
dc.subject.otherelectron transfer*
dc.subject.othernanotechnology*
dc.subject.otheriron deficiency*
dc.subject.otherneonatal period*
dc.subject.otherheme oxygenase*
dc.subject.otherhypoxia*
dc.subject.otherAnemia*
dc.subject.otherNCOA4*
dc.subject.otherpatient blood management*
dc.subject.othermicrobiome*
dc.subject.otheranemia*
dc.subject.otheriron mobilization*
dc.subject.otheriron release*
dc.subject.otherphlebotomy*
dc.subject.otherperitoneal dialysis*
dc.subject.otherFriedreich Ataxia*
dc.subject.otherferritin*
dc.subject.otherCD8+ T cells*
dc.subject.otherM cells*
dc.subject.otherneurodegenerative disease*
dc.subject.otherNaFeEDTA*
dc.subject.othervascular calcification*
dc.subject.othercinnamic acid derivatives*
dc.subject.otheroral iron salts*
dc.subject.otherlipid*
dc.subject.otheracute lung injury*
dc.subject.otherIron-sulfur*
dc.subject.otherInterleukin-6*
dc.subject.otherneurodegeneration with brain iron accumulation*
dc.subject.othermacrophages*
dc.subject.othererythroblastic islands*
dc.subject.othercystic fibrosis*
dc.subject.otherneuroimmune responses*
dc.subject.otherflavin nucleotide*
dc.subject.otherhemopexin*
dc.subject.otherIron chelators*
dc.subject.othernutrient iron*
dc.subject.otherdeveloping countries*
dc.subject.otherhereditary hypoferritinemia*
dc.subject.otheriron*
dc.subject.othercancer*
dc.subject.otherIndonesia*
dc.subject.othern/a*
dc.subject.otherHfe*
dc.subject.otherHFE*
dc.subject.otherchronic heart failure*
dc.subject.otheriron supplementation*
dc.subject.otherintestinal inflammation*
dc.subject.otherTNF*
dc.subject.otherchelators*
dc.subject.otherhemolysis*
dc.subject.otherchildren*
dc.subject.otherpulmonary arterial smooth muscle cells*
dc.subject.othercytokines*
dc.subject.otherdidox*
dc.subject.otherintravenous iron*
dc.subject.otherT lymphocytes*
dc.subject.othercolorectal cancer*
dc.subject.otherinfants*
dc.subject.otherliver*
dc.subject.otherferritinophagy*
dc.subject.otherhereditary hyperferritinemia*
dc.subject.otherSCFA*
dc.subject.otherrheumatoid arthritis*
dc.subject.othermembrane interactions*
dc.subject.otherSucrosomial® iron*
dc.subject.otherlung*
dc.subject.otherKupffer cell*
dc.subject.otheriron chelation*
dc.subject.othererythrophagocytosis*
dc.subject.otheracute kidney injury*
dc.subject.otherneurophysiology*
dc.subject.otheriron transporters*
dc.subject.otheriron absorption*
dc.subject.otherinfection*
dc.subject.otherferroptosis*
dc.subject.otherfluorescent iron chelator*
dc.subject.otherneonatal*
dc.subject.otherSNC*
dc.subject.otherimmunity*
dc.subject.othermycobacteria*
dc.subject.othernon-haem iron*
dc.subject.othernatural history*
dc.subject.other3-hydroxy-4-pyridinone*
dc.subject.otherhaem*
dc.subject.otherinflammation*
dc.subject.otherbone homeostasis*
dc.subject.othercardiovascular disease*
dc.subject.otherheme*
dc.subject.otherheme homeostasis*
dc.subject.otherprotein binding*
dc.subject.otherbrain*
dc.subject.otheriron deficiency anemia*
dc.subject.otherFe2+-chelating activity*
dc.subject.otherbioengineering*
dc.subject.otherMek/Erk*
dc.subject.otherBmp/Smad*
dc.subject.otheriron delivery*
dc.subject.othergenetic hemochromatosis*
dc.subject.otherosteoclast*
dc.subject.otherhistidine*
dc.subject.otherrhodamine*
dc.subject.otherCOPD*
dc.subject.otherhemorrhage*
dc.subject.otherantibacterial activity*
dc.subject.otherbacteria*
dc.subject.otherSLC40A1*
dc.subject.othertransferrin receptor*
dc.subject.otherdrug delivery*
dc.subject.othernanocage*
dc.subject.othersoybean seed ferritin*
dc.subject.otherpig*
dc.subject.otheriron metabolism*
dc.subject.otherkidney*
dc.subject.otherinnate immunity*
dc.subject.othercataracts syndrome*
dc.subject.othererythropoiesis*
dc.subject.otherobesity*
dc.subject.othermucosal immunity*
dc.subject.otheriron overload*
dc.subject.otherfluorophore*
dc.subject.otherbinding ability*
dc.subject.otherinflammatory bowel disease (IBD)*
dc.subject.otherosteoporosis*
dc.subject.otherbiomarker*
dc.subject.otherbioavailability*
dc.subject.otheradverse event profile*
dc.subject.othermetabolism*
dc.subject.otheriron-carbohydrate complex*
dc.subject.otherkinetics*
dc.subject.otherflavonoids*
dc.subject.otheriron regulatory proteins*
dc.subject.otherlung infection*
dc.subject.othernon transferrin bound iron*
dc.subject.othercentral nurse macrophage*
dc.subject.otheriron processing*
dc.subject.othermalaria*
dc.subject.otherneurodegenerative diseases*
dc.subject.othermultifunctional iron chelators*
dc.subject.otherretina*
dc.subject.otherneuroinflammation*
dc.subject.otheranti-hepcidin therapy*
dc.subject.otherlung diseases*
dc.subject.otheranaemia*
dc.subject.otherRRM2*
dc.subject.othercognition*
dc.subject.othermitochondria*
dc.subject.othertherapy*
dc.subject.otherNBIA*
dc.subject.otherred pulp macrophage*
dc.subject.otherefficacy*
dc.subject.otherhemochromatosis*
dc.subject.othertolerability*
dc.subject.otheroral iron therapy*
dc.subject.othergrowth*
dc.subject.othervenesections*
dc.titleIron as Therapeutic Targets in Human Diseases Volume 2*
dc.typebook
oapen.identifier.doi10.3390/books978-3-03928-115-2*
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0*
virtual.oapen_relation_isPublishedBy.publisher_nameMDPI - Multidisciplinary Digital Publishing Institute
virtual.oapen_relation_isPublishedBy.publisher_websitewww.mdpi.com/books
oapen.relation.isbn9783039281152*
oapen.relation.isbn9783039281145*
oapen.pages440*
oapen.edition1st*


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