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dc.contributor.authorSilvia Gregori*
dc.contributor.authorJoel LeMaoult*
dc.date.accessioned2021-02-11T15:28:14Z
dc.date.available2021-02-11T15:28:14Z
dc.date.issued2017*
dc.date.submitted2017-07-06 13:27:36*
dc.identifier22970*
dc.identifier.issn16648714*
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/49487
dc.description.abstractThe non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.*
dc.languageEnglish*
dc.relation.ispartofseriesFrontiers Research Topics*
dc.subjectR5-920*
dc.subjectRC581-607*
dc.subject.otherPregnancy*
dc.subject.otherAutoimmunity*
dc.subject.otherImmuno-modulation*
dc.subject.otherPre-Eclampsia*
dc.subject.otherInfections*
dc.subject.otherExosomes*
dc.subject.otherHLA-G*
dc.subject.otherpolymorphisms*
dc.subject.othertolerance*
dc.subject.otherCancer*
dc.titleHLA-G-mediated Immune Tolerance: Past and New Outlooks*
dc.typebook
oapen.identifier.doi10.3389/978-2-88945-119-7*
oapen.relation.isPublishedBybf5ce210-e72e-4860-ba9b-c305640ff3ae*
virtual.oapen_relation_isPublishedBy.publisher_nameFrontiers Media SA
virtual.oapen_relation_isPublishedBy.publisher_websitewww.frontiersin.org
oapen.relation.isbn9782889451197*
oapen.pages92*


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