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dc.contributor.authorBermejo, Marival*
dc.date.accessioned2021-02-11T14:17:38Z
dc.date.available2021-02-11T14:17:38Z
dc.date.issued2020*
dc.date.submitted2020-04-07 23:07:09*
dc.identifier44840*
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/48301
dc.description.abstractThis book presents some of the state-of-the-art methods for the study of the gastrointestinal variables affecting oral drug absorption. Practical applications of new in vitro release/dissolution methods are presented, as well as in vitro permeability studies to explore segmental differences. The application of MRI methods for the study of colon physiology is presented to illustrate its potential applications in controlled release dosage form design. Some examples of successful in vitro–in vivo correlations show how implementing the gastrointestinal physiological variables in the new in vitro methods can improve the predictions of in vivo drug product performance. The book contains an updated review of the experimental, computational, and in vivo approaches for measuring intestinal permeability.*
dc.languageEnglish*
dc.subjectR5-920*
dc.subjectRM1-950*
dc.subject.otherin vitro dissolution*
dc.subject.othermicroscopy imaging*
dc.subject.othermodulation*
dc.subject.otherionotropic gelation*
dc.subject.otherlaponite*
dc.subject.otherbiowaiver*
dc.subject.otherbeads*
dc.subject.othermodel*
dc.subject.otherpolymer/clay composite*
dc.subject.otherflow*
dc.subject.otherbioequivalence*
dc.subject.otheroral absorption*
dc.subject.othercurcumin*
dc.subject.otherP-gp*
dc.subject.otherliquid–liquid phase separation*
dc.subject.otherabsorption*
dc.subject.otherlarge bowel*
dc.subject.otherdissolution*
dc.subject.otherUssing chamber*
dc.subject.otherswelling*
dc.subject.otherfimasartan*
dc.subject.othervolume*
dc.subject.otherdexketoprofen*
dc.subject.othergastrointestinal simulator*
dc.subject.othertransit*
dc.subject.othercontrolled release formulations*
dc.subject.otherexperimental and computational permeability methods*
dc.subject.othermagnetic resonance imaging*
dc.subject.otherGastroPlus™*
dc.subject.otherin vitro–in vivo correlation (IVIVC)*
dc.subject.otherdiltiazem*
dc.subject.otherMRI*
dc.subject.othergut*
dc.subject.otherin vitro systems*
dc.subject.otherCYP3A4*
dc.subject.otherpoorly water-soluble drugs*
dc.subject.otherregional absorption*
dc.subject.otherintestinal permeability*
dc.subject.otherbutyric acid*
dc.subject.otherintestinal drug absorption*
dc.subject.othergastrointestinal absorption*
dc.subject.otherBiopharmaceutics Classification System (BCS)*
dc.subject.otheranti-inflammatory*
dc.subject.otherin vivo*
dc.subject.othercolon microbiota*
dc.subject.otherlipid-based formulations*
dc.subject.otherin situ single-pass perfusion*
dc.subject.othermetabolites*
dc.subject.otherbiorelevant media*
dc.subject.otherfluconazole*
dc.subject.othercolon delivery*
dc.subject.othermodeling study*
dc.subject.othermathematical modeling*
dc.subject.othermotility*
dc.subject.othergellan gum*
dc.subject.othergastrointestinal drug release*
dc.subject.otherlarge intestine*
dc.subject.otherlipolysis*
dc.subject.otherregional drug absorption*
dc.titleGastrointestinal Variables and Drug Absorption: Experimental, Computational and In Vitro Predictive Approaches*
dc.typebook
oapen.identifier.doi10.3390/books978-3-03928-493-1*
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0*
oapen.relation.isbn9783039284931*
oapen.relation.isbn9783039284924*
oapen.pages206*
oapen.edition1st*


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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/