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dc.contributor.authorLee, Hye Suk*
dc.contributor.authorLiu, Kwang-Hyeon*
dc.date.accessioned2021-02-11T11:49:09Z
dc.date.available2021-02-11T11:49:09Z
dc.date.issued2019*
dc.date.submitted2019-06-26 08:44:06*
dc.identifier33676*
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/45509
dc.description.abstractDrug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.*
dc.languageEnglish*
dc.subjectR5-920*
dc.subjectRM1-950*
dc.subject.otherhuman liver microsomes*
dc.subject.otheralcohol addiction*
dc.subject.otherUGT*
dc.subject.otherultra-high-pressure liquid chromatography*
dc.subject.otheradalimumab*
dc.subject.otherprocainamide*
dc.subject.otherLC-MS/MS*
dc.subject.otherDA-9805*
dc.subject.otherpaeonol*
dc.subject.otherLC-QTOF-MS/MS*
dc.subject.otherYRA-1909*
dc.subject.otherchlorogenic acid*
dc.subject.otherimmunoprecipitation*
dc.subject.otherEurycoma longifolia*
dc.subject.otherCYP*
dc.subject.othercaffeic acid*
dc.subject.otherrat*
dc.subject.otherpharmaceutical excipient*
dc.subject.otherKorean red ginseng extract*
dc.subject.otherStauntonia hexaphylla leaf extract*
dc.subject.otherbioanalysis*
dc.subject.otherHPLC-MS/MS*
dc.subject.otherB6*
dc.subject.othereurycomanone*
dc.subject.otherbioavailability*
dc.subject.otherdrying technology*
dc.subject.otherGB3*
dc.subject.otherdiclofenac*
dc.subject.other129-Glatm1Kul/J*
dc.subject.otheraglycone*
dc.subject.othercaffeic acid O-glucuronides*
dc.subject.otherorganic anion transporting polypeptide*
dc.subject.otherprotein precipitation*
dc.subject.othermetabolic stability*
dc.subject.otherFabry disease*
dc.subject.otherbiopharmaceuticals*
dc.subject.otherimperatorin*
dc.subject.otherneochlorogenic acid*
dc.subject.othergastric ulcer*
dc.subject.othersaikosaponin a*
dc.subject.otherhair*
dc.subject.otheranthraquinone*
dc.subject.otheracetyl tributyl citrate*
dc.subject.otherpharmacokinetics*
dc.subject.otherbrain distribution*
dc.subject.othermematine*
dc.subject.otherethyl glucuronide*
dc.subject.otherpharmacokinetic*
dc.subject.otherloxoprofen*
dc.subject.otherliquid chromatography-quadrupole TOF MS*
dc.subject.otherglucuronidation*
dc.subject.otheresomeprazole*
dc.subject.othermetformin*
dc.subject.othercytochrome P450*
dc.subject.otherglycoside*
dc.subject.otherAUDIT score*
dc.subject.otherprotein stability*
dc.subject.otherefficacy*
dc.subject.otherLC-HR/MS*
dc.subject.othercryptochlorogenic acid*
dc.subject.otheraceclofenac*
dc.subject.otherdrug interaction*
dc.subject.otherliquid chromatography-tandem mass spectrometry*
dc.subject.otherOsthenol*
dc.subject.otherplasma*
dc.subject.otherN-acetylprocainamide*
dc.subject.otherdiabetes*
dc.titleDrug Metabolism, Pharmacokinetics and Bioanalysis*
dc.typebook
oapen.identifier.doi10.3390/books978-3-03897-917-3*
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0*
virtual.oapen_relation_isPublishedBy.publisher_nameMDPI - Multidisciplinary Digital Publishing Institute
virtual.oapen_relation_isPublishedBy.publisher_websitewww.mdpi.com/books
oapen.relation.isbn9783038979166*
oapen.relation.isbn9783038979173*
oapen.pages230*
oapen.edition1st*


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