Astrocytic-neuronal-astrocytic Pathway Selection for Formation and Degradation of Glutamate/GABA
Auteur
Tiago B. Rodrigues
Leif Hertz
Language
EnglishRésumé
Endocrinological research early recognized the importance of intercellular interactions and realized the importance of glutamatergic and GABAergic signaling. In turn this signalling depends on elaborate interactions between astrocytes and neurons, without which neurons would be unable to produce, reuse and metabolize transmitter glutamate and GABA. Details of these subjects are described in this Research Topic by key investigators in this field. It focuses on the intricate and extremely swift pathway producing these amino acid transmitters from glucose in brain but also discusses difficulties in determining expression of some of the necessary genes in astrocytes and related processes in pancreatic islets. However, it does not discuss how closely associated astrocytes and neurons are anatomically, enabling these interactions. This is elegantly shown in this cover image, kindly provided by Professor Andreas Reichenbach (University of Leipzig, Germany).
Keywords
Brain glutamine; brain metabolism; Appetite Regulation; Astrocyte-oligdendrocyte interaction; Brain ammonia; GABA; Astrocytic gene expression; pancreatic islets; Brain aspartate; Brain glutamateWebshop link
http://www.frontiersin.org/boo ...ISBN
9782889192434Publisher
Frontiers Media SAPublisher website
www.frontiersin.orgPublication date and place
2014Series
Frontiers Research Topics,Classification
Medicine and Nursing