Cavitation-Enhanced Drug Delivery and Immunotherapy

doi:10.3390/books978-3-0365-9435-4

Download Url(s)

https://mdpi.com/books/pdfview/book/8293

Contributor(s)

Helfield, Brandon (editor)

Sirsi, Shashank (editor)

Kwan, James (editor)

Gray, Michael (editor)

Language

English

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Abstract

Cavitation-Enhanced Drug Delivery and Immunotherapy is a rapidly evolving area that has been buoyed in recent years by the development of methods harnessing the activity of ultrasound-stimulated bubbles, known as cavitation. When properly controlled, cavitation can help overcome physical barriers to drug delivery whilst providing readily measurable information for timely quantitative feedback and treatment guidance. Microbubble-assisted therapies have demonstrated impressive advancements in clinical trials and pre-clinical areas, including applications in neurology, oncology, cardiology and beyond.

URI

https://directory.doabooks.org/handle/20.500.12854/128825

Keywords

passive cavitation detection; size-isolated microbubbles; focused ultrasound; stable cavitation; inertial cavitation; perfluoropentane microdroplets; cavitation; microfluidic emulsion manufacturing; polydispersity; ultrasound contrast agent; ultrasound duty cycle; intravascular ultrasound; ultrasound; targeted drug delivery; microbubble; sonoporation; nanoparticle; gene therapy; miRNA delivery; microRNA-126; microbubbles; endothelial cells; HUVEC; therapeutic angiogenesis; round window membrane; metabolomics; perilymph; inner ear; SonoCloud; GL261 mouse model; ultrasound-mediated drug delivery; glioblastoma; immune checkpoint inhibitors; radiotherapy; tumor hypoxia; contrast-enhanced ultrasound; oxygen-loaded microbubbles; drug delivery; head and neck cancer; lonidamine; metformin; cavitation nuclei; Biofilm; microbubble targeting; cationic microbubble; ultrasound drug delivery; pancreatic cancer; paclitaxel; gemcitabine; cetuximab; SonoTran Particles; passive acoustic mapping; large animal cancer model; targeted microbubbles; ultrasound imaging probes; ultrasound-targeted delivery; therapy; immunotherapy; ultrasound targeting; acoustic droplet vaporization; cancer; checkpoint inhibitor; n/a