TY  - BOOK
AU  - Kim, Seoung-Eun
AB  - The most commonly used measurement technique for electrophysiology is the patch clamp technique. While this measurement technique allows the precise investigation of the communication taking place through ion channels, it has some undesirable drawbacks such as the local destruction of the plasma membrane, a low success rate and an elaborate experimental procedure. To avoid these drawbacks, in this work a new non-invasive microfluidic platform for electrophysiological research (NIMEP) was developed with regard to the activity of ion channels. This novel approach is based on the non-invasive measurement of the total current through the cell membrane and provides a possibility for an automated investigation of the individual cells. In addition, the investigated cell can be used for other applications, since the cell remains in an intact state before and after the test.
DO  - 10.5445/KSP/1000046877
ID  - OAPEN ID: 34413
KW  - Nicht-invasiv
KW  - Mikrofluidik
KW  - Non-invasive
KW  - Patch clamp technique
KW  - Ionenkanal
KW  - Electrophysiology
KW  - Elektrophysiologie
KW  - Ion channel
KW  - Patch-Clamp-Technik
KW  - Microfluidics
L1  - https://www.ksp.kit.edu/9783731503781
LA  - German
LK  - https://directory.doabooks.org/handle/20.500.12854/51179
PB  - KIT Scientific Publishing
PY  - 2015
SN  - 9783731503781
TI  - Konzeption und prototypische Fertigung einer nicht-invasiven mikrofluidischen Plattform für die Elektrophysiologie (NIMEP) zur Zellenanalysenull
ER  - 
