TY  - BOOK
AU  - Hong, Kui
AU  - Zhang, Changsheng
AU  - Dobson, Alan
AB  - Two review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Examples include the rational supply of precursors according to the relevant biosynthetic pathway and stress driven discovery together with the use of histone deacetylase inhibitors to facilitate the discovery of new bioactive molecules with potential biopharmaceutical applications. We believe that the content of this Special Issue reflects the current state-of-the-art research in this area and highlights the interesting strategies that are being employed to uncover increasing numbers of exciting novel compounds for drug discovery from marine genetic resources.
DO  - 10.3390/books978-3-03928-091-9
ID  - OAPEN ID: 43618
KW  - antibacterial activity
KW  - polyketide synthase
KW  - halo-extremophyles
KW  - antibacterial
KW  - gene cluster
KW  - Penicillium chrysogenum
KW  - bacillomycin
KW  - secondary metabolites
KW  - drug discovery
KW  - biosynthesis
KW  - polycyclic tetramate macrolactams
KW  - actinobacteria
KW  - biosynthetic gene clusters
KW  - phylotype
KW  - comparative genomics
KW  - IclR family regulator
KW  - polyketide antibiotics
KW  - antifungal
KW  - fatty acid amide
KW  - Antarctica
KW  - marine microorganisms
KW  - NdgRyo
KW  - nonribosomal peptides
KW  - Marisediminicola
KW  - genome mining
KW  - antimicrobial
KW  - sponge
KW  - Stachybotrys
KW  - carotenoid
KW  - marine
KW  - archaea
KW  - haloenzymes
KW  - natural products
KW  - Streptomyces sp. SCSIO 40010
KW  - 16S rRNA metagenomics
KW  - ecotype
KW  - medicinal chemistry
KW  - cytotoxicity
KW  - marine natural products (MNPs)
KW  - Streptomyces
KW  - marine Bacillus
KW  - antimicrobial activity
KW  - amino compound
KW  - bacillibactin
KW  - meroterpenoid
KW  - fibrinolytic activity
KW  - metal stress technique
KW  - isoindolinone biosynthesis
KW  - Streptomyces pratensis
KW  - histone-deacetylase inhibitor
KW  - marine natural product
KW  - Odiel marshlands
L1  - https://www.mdpi.com/books/pdfview/book/1926
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/48415
PB  - MDPI - Multidisciplinary Digital Publishing Institute
PY  - 2020
SN  - 9783039280919
SN  - 9783039280902
TI  - Genome Mining and Marine Microbial Natural Productsnull
ER  - 
