TY  - BOOK
AU  - Megan Chircop
AU  - Daniel Speidel
AB  - In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or elimination of damaged and pre-malignant cells. Thus, a large number of anti-cancer agents target specific components of stress response signalling pathways with the aim of causing tumour regression by stimulating cell death. However, the efficacy of these agents is often impaired due to mutations in genes that are involved in these stress-responsive signalling pathways and instead the oncogenic potential of a cell is increased leading to the initiation and/or progression of tumourigenesis. Moreover, these genetic defects can increase or contribute to resistance to chemotherapeutic agents and/or radiotherapy. Modulating the outcome of cellular stress responses towards cell death in tumour cells without affecting surrounding normal cells is thus one of the ultimate aims in the development of new cancer therapeutics. To achieve this aim, a detailed understanding of cellular stress response pathways and their aberrations in cancer is required.This Research topic aims to reflect the broadness and complexity of this important area of cancer research.
DO  - 10.3389/978-2-88919-496-4
ID  - OAPEN ID: 17684
KW  - DNA Repair
KW  - DNA Damage
KW  - tumorigenesis
KW  - therapeutic targets
KW  - chemotherapy
KW  - Apoptosis
KW  - cellular stress
KW  - therapy resistance
L1  - http://journal.frontiersin.org/researchtopic/1922/molecular-mechanisms-of-cellular-stress-responses-in-cancer-and-their-therapeutic-implications
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/53849
PB  - Frontiers Media SA
PY  - 2015
SN  - 9782889194964
TI  - Molecular mechanisms of cellular stress responses in cancer and their therapeutic implicationsnull
ER  - 
