TY  - BOOK
AU  - Enrique Cadenas
AU  - Jia Yao
AU  - Fei Yin
AU  - Roberta Diaz Brinton
AB  - Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer’s disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Nevertheless, multiple lines of evidence support the notion that mitochondrial dysfunction and chronic inflammation exacerbate each other, and these mechanistic diversities have cellular redox dysregulation as a common denominator. This research topic focuses on the role of a metabolic-inflammatory axis encompassing the bioenergetic activity, brain inflammatory responses and their redox regulation in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems are reviewed in terms of their causative or in-tandem occurrence and how the systemic environment, –e.g., insulin resistance, diabetes, and systemic inflammation–, impacts on brain function.
DO  - 10.3389/978-2-88945-253-8
ID  - OAPEN ID: 25567
KW  - Brain aging
KW  - Mitochondria
KW  - Energy Metabolism
KW  - neurodegeneration
KW  - Neuroinflammation
KW  - Perimenopause
KW  - redox homeostasis
KW  - Alzheimer's disease
KW  - diabetes
L1  - http://journal.frontiersin.org/researchtopic/2807/the-metabolic-inflammatory-axis-in-brain-aging-and-neurodegeneration
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/53229
PB  - Frontiers Media SA
PY  - 2017
SN  - 9782889452538
TI  - The Metabolic-Inflammatory Axis in Brain Aging and Neurodegenerationnull
ER  - 
