TY  - BOOK
AU  - Bachmeier, Beatrice
AB  - The plant-derived polyphenol curcumin has been used in promoting health and combating disease for thousands of years. Its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecular research reveal the modulatory effects of curcumin on a variety of signal transduction pathways associated with inflammation and cancer. In this context, curcumin’s antioxidant, anti-inflammatory, anti-tumorigenic, and even anti-metastatic activities are discussed. On the cellular level, the reduced activity of several transcription factors (such as NFkB or AP-1) and the suppression of inflammatory cytokines, matrix degrading enzymes, metastasis related genes and even microRNAs are reported. On functional levels, these molecular effects translate into reduced proliferative, invasive, and metastatic capacity, as well as induced tumor cell apoptosis. All these effects have been observed not only in vitro but also in animal models. In combination with anti-neoplastic drugs like Taxol, kinase inhibitors, and radiation therapy, curcumin potentiates the drugs’ therapeutic power and can protect against undesired side effects. Natural plant-derived compounds like curcumin have one significant advantage: They do not usually cause side effects. This feature qualifies curcumin for primary prevention in healthy persons with a predisposition to cancer, arteriosclerosis, or chronic inflammatory diseases. Nonetheless, curcumin is considered safe, although potential toxic effects stemming from high dosages, long-term intake, and pharmacological interactions with other compounds have yet to be assessed. This Special Issue examines in detail and updates current research on the molecular targets, protective effects, and modes of action of natural plant-derived compounds and their roles in the prevention and treatment of human diseases.
DO  - 10.3390/books978-3-03921-450-1
ID  - OAPEN ID: 42573
KW  - minerals
KW  - cancer treatment
KW  - chitosan
KW  - n/a
KW  - neurodegeneration
KW  - antioxidant activity
KW  - senescence
KW  - tumor proliferation
KW  - nanoparticles
KW  - antimicrobial agents
KW  - oxidative metabolites
KW  - drug discovery
KW  - Akt/mTOR signaling
KW  - micronutrients
KW  - ulcerative colitis
KW  - transmission electron microscopy
KW  - metabolic reprogramming
KW  - curcumin
KW  - death receptor
KW  - chaperone-mediated autophagy
KW  - wound healing
KW  - brain ischemia
KW  - autophagy
KW  - Alzheimer’s disease
KW  - genes
KW  - transthyretin
KW  - inflammatory bowel disease
KW  - cellular pathway
KW  - centrifugal partition chromatography
KW  - nutrition
KW  - amyloid
KW  - Curcuma longa
KW  - protein aggregation
KW  - supportive care
KW  - IL-17
KW  - senolytics
KW  - complementary medicine
KW  - macronutrients
KW  - structure activity relationship
KW  - gastroprotection
KW  - Zingiberaceae
KW  - anti-inflamation
KW  - TLC bioautography
KW  - microbiota
KW  - glioblastoma multiforme
KW  - amyloidosis
KW  - SHMT2
KW  - antioxidants
KW  - silica
KW  - apoptosis
KW  - reflux esophagitis
KW  - gastric ulcer
KW  - TLC-MS
KW  - anti-cancer
KW  - anticancer
KW  - ImageJ
KW  - anti-tumor
KW  - delivery system
KW  - wound
KW  - Helicobacter pylori
KW  - direct protein binding
KW  - protein misfolding
KW  - tumor growth
KW  - diet
KW  - Crohn’s disease
KW  - hydrostatic counter-current chromatography
KW  - ageing
KW  - renal cell cancer
KW  - gastric cancer
KW  - amino-acids
KW  - STAT3
KW  - mechanism of action
KW  - inflamm-aging
KW  - mitophagy
KW  - necrotizing enterocolitis
KW  - cell cycling
KW  - vitamins
KW  - turmeric tuber
KW  - cancer
KW  - tau protein
L1  - https://mdpi.com/books/pdfview/book/1668
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/44401
PB  - MDPI - Multidisciplinary Digital Publishing Institute
PY  - 2019
SN  - 9783039214495
SN  - 9783039214501
TI  - Curcumin in Health and Diseasenull
ER  - 
