TY - BOOK AU - Lidbury, Brett AU - Fisher, Paul AB - Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS. DO - 10.3390/books978-3-03928-391-0 ID - OAPEN ID: 44823 KW - fatigue syndrome KW - n/a KW - work rehabilitation KW - tryptophan metabolism KW - substrate inhibition KW - myalgic encephalomyelitis KW - 3-dioxygenase KW - ME (Myalgic Encephalomyelitis) KW - assessment KW - myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) KW - muscles KW - hypoacetylation KW - circadian rhythm KW - immune system KW - chronic KW - CFS (Chronic Fatigue Syndrome) KW - energy metabolism KW - ME/CFS KW - immunological KW - cytokine KW - bistability KW - diagnosis KW - biomarker KW - symptoms KW - kynurenine pathway KW - inflammation and immunity KW - metabolism KW - neuro-inflammation KW - pathology KW - signaling KW - exercise KW - Epstein Barr virus KW - methylhistidine KW - hypothalamic–pituitary–adrenal axis KW - potential biomarkers KW - critical point KW - inflammation KW - histone deacetylation KW - participatory research KW - neurology KW - neuroimmune KW - activin KW - mitochondria KW - patient-driven questionnaire KW - medical retirement KW - machine learning KW - prognosis KW - gut microbiota KW - post-exertional malaise KW - chronic fatigue syndrome KW - mathematical model KW - reference intervals KW - diagnostic biomarker KW - indoleamine-2 L1 - https://mdpi.com/books/pdfview/book/2100 LA - English LK - https://directory.doabooks.org/handle/20.500.12854/42280 PB - MDPI - Multidisciplinary Digital Publishing Institute PY - 2020 SN - 9783039283910 SN - 9783039283903 TI - Biomedical Insights that Inform the Diagnosis of ME/CFSnull ER -