TY  - BOOK
AU  - Fernando A. Arosa
AB  - Human CD8+ T cells expressing NK receptors and receptors found on innate immune cells, and designated as NK-like or innate CD8+ T cells, have been long considered as terminally differentiated lymphocytes responsible for tissue inflammation and destruction. However, a growing body of knowledge is unveiling that NK-like CD8+ T cells have many, sometimes contrasting, functions. The limited knowledge of the biology of this type of CD8+ T cells and the role they play within peripheral tissues and organs under homeostatic conditions has hampered our understanding of disease and therefore the possible development of disease diagnostic tools and effective immunotherapies. In this Research Topic are presented a variety of topics and views, some of them overlooked for many years, on human NK-like CD8+ T cells, which may open new and novel avenues of research to further our understanding of these polyfunctional T cells.
DO  - 10.3389/978-2-88945-396-2
ID  - OAPEN ID: 29628
KW  - Open conformers
KW  - Disease control
KW  - Adaptive
KW  - Innate receptors
KW  - Successful aging
KW  - Regulatory
KW  - Suppressor
KW  - Tissue repair
KW  - Cytotoxic
KW  - MHC class I
L1  - https://www.frontiersin.org/research-topics/4775/on-the-origin-and-function-of-human-nk-like-cd8-t-cells-charting-new-territories
LA  - English
LK  - https://directory.doabooks.org/handle/20.500.12854/55215
PB  - Frontiers Media SA
PY  - 2018
SN  - 9782889453962
TI  - On the Origin and Function of Human NK-like CD8+ T Cells: Charting New Territoriesnull
ER  - 
